Document Detail

Delayed expulsion of the nematode Nippostrongylus brasiliensis from rats on a low protein diet: the role of a bone marrow derived component.
MedLine Citation:
PMID:  7010987     Owner:  NLM     Status:  MEDLINE    
Rats on a low protein diet, containing 10% casein as the only source of protein, have an impaired capacity to expel primary infections with the nematode Nippostrongylus brasiliensis and remain susceptible to reinfection. In the present study, the transfer of syngeneic bone marrow cells to rats on a low protein diet reconstituted the expulsion mechanism allowing parasite rejection to occur at the same rate as rats on a sufficient diet. Serum transfer, on the other hand, did not significantly alter the rate of worm expulsion. These results demonstrate that a bone marrow derived component plays an important role in the impaired immunity of rats fed a low protein diet.
V M Duncombe; T D Bolin; A E Davis; J D Kelly
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  34     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  400-3     Citation Subset:  AIM; IM    
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MeSH Terms
Bone Marrow / immunology
Bone Marrow Cells
Bone Marrow Transplantation*
Dietary Proteins / administration & dosage*
Immune Sera
Nematode Infections / therapy*
Protein Deficiency / immunology
Transplantation, Isogeneic
Reg. No./Substance:
0/Dietary Proteins; 0/Immune Sera

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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