| Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice. | |
| | |
MedLine Citation:
|
PMID: 12858040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The neuropeptide nociceptin/orphanin FQ (N/OFQ) is implicated in many biological functions, including nociception, locomotor activity, stress and anxiety, drinking and food-intake. N/OFQ has also been reported to play a facilitatory role in acute kainate-induced seizures. The aim of the present study was to investigate its involvement in a chronic model of temporal lobe epilepsy, kindling epileptogenesis, using N/OFQ knock-out mice and their wild-type littermates as controls. Kindling development was retarded in N/OFQ-deficient mice, in that (compared with controls) they required a significantly greater number of stimulations and a significantly longer time in electrical seizures to reach kindling criteria. These data indicate that N/OFQ is involved in the development of kindling and that it may play a pro-epileptogenic role. |
| | |
Authors:
|
Anna Binaschi; Silvia Zucchini; Gianni Bregola; Donata Rodi; Manuela Mazzuferi; Rainer K Reinscheid; Michele Simonato |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuroreport Volume: 14 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2003 May |
Date Detail:
|
Created Date: 2003-07-14 Completed Date: 2003-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
|
Languages: eng Pagination: 825-7 Citation Subset: IM |
Affiliation:
|
Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, via Fossato di Mortara 17-19, 44100 Ferrara, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Epilepsy / metabolism Epilepsy, Temporal Lobe / metabolism*, physiopathology Excitatory Amino Acids / agonists Kindling, Neurologic / metabolism* Male Mice Mice, Inbred C57BL Mice, Knockout Opioid Peptides / deficiency*, genetics |
| Chemical | |
Reg. No./Substance:
|
0/Excitatory Amino Acids; 0/Opioid Peptides; 0/nociceptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Noise induces up-regulation of P2X2 receptor subunit of ATP-gated ion channels in the rat cochlea.
Next Document: Sensitivity to horizontal and vertical disparity and orientation preference in areas V1 and V2 of th...