Document Detail

Delayed epileptogenesis in nociceptin/orphanin FQ-deficient mice.
MedLine Citation:
PMID:  12858040     Owner:  NLM     Status:  MEDLINE    
The neuropeptide nociceptin/orphanin FQ (N/OFQ) is implicated in many biological functions, including nociception, locomotor activity, stress and anxiety, drinking and food-intake. N/OFQ has also been reported to play a facilitatory role in acute kainate-induced seizures. The aim of the present study was to investigate its involvement in a chronic model of temporal lobe epilepsy, kindling epileptogenesis, using N/OFQ knock-out mice and their wild-type littermates as controls. Kindling development was retarded in N/OFQ-deficient mice, in that (compared with controls) they required a significantly greater number of stimulations and a significantly longer time in electrical seizures to reach kindling criteria. These data indicate that N/OFQ is involved in the development of kindling and that it may play a pro-epileptogenic role.
Anna Binaschi; Silvia Zucchini; Gianni Bregola; Donata Rodi; Manuela Mazzuferi; Rainer K Reinscheid; Michele Simonato
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  14     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-07-14     Completed Date:  2003-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  825-7     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, Section of Pharmacology, and Neuroscience Center, University of Ferrara, via Fossato di Mortara 17-19, 44100 Ferrara, Italy.
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MeSH Terms
Epilepsy / metabolism
Epilepsy, Temporal Lobe / metabolism*,  physiopathology
Excitatory Amino Acids / agonists
Kindling, Neurologic / metabolism*
Mice, Inbred C57BL
Mice, Knockout
Opioid Peptides / deficiency*,  genetics
Reg. No./Substance:
0/Excitatory Amino Acids; 0/Opioid Peptides; 0/nociceptin

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