| Delayed enteral feeding impairs intestinal carbohydrate absorption in critically ill patients. | |
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MedLine Citation:
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PMID: 21926614 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES:: Delay in initiating enteral nutrition has been reported to disrupt intestinal mucosal integrity in animals and to prolong the duration of mechanical ventilation in humans. However, its impact on intestinal absorptive function in critically ill patients is unknown. The aim of this study was to examine the impact of delayed enteral nutrition on small intestinal absorption of 3-O-methyl-glucose. DESIGN:: Prospective, randomized study. SETTING:: Tertiary critical care unit. PATIENTS:: Studies were performed in 28 critically ill patients. INTERVENTIONS:: Patients were randomized to either enteral nutrition within 24 hrs of admission (14 "early feeding": 8 males, 6 females, age 54.9 ± 3.3 yrs) or no enteral nutrition during the first 4 days of admission (14 "delayed feeding": 10 males, 4 females, age 56.1 ± 4.2 yrs). MEASUREMENTS AND MAIN RESULTS:: Gastric emptying (scintigraphy, 100 mL of Ensure with 20 MBq Tc-suphur colloid), intestinal absorption of glucose (3 g of 3-O-methyl-glucose), and clinical outcomes were assessed 4 days after intensive care unit admission. Although there was no difference in gastric emptying, plasma 3-O-methyl-glucose concentrations were less in the patients with delayed feeding compared to those who were fed earlier (peak: 0.24 ± 0.04 vs. 0.37 ± 0.04 mmol/L, p < .02) and integrated (area under the curve at 240 mins: 38.5 ± 7.0 vs. 63.4 ± 8.3 mmol/L/min, p < .04). There was an inverse correlation between integrated plasma concentrations of 3-O-methyl-glucose (area under the curve at 240 mins) and the duration of ventilation (r = -.51; p = .006). In the delayed feeding group, both the duration of mechanical ventilation (13.7 ± 1.9 vs. 9.2 ± 0.9 days; p = .049) and length of stay in the intensive care unit (15.9 ± 1.9 vs. 11.3 ± 0.8 days; p = .048) were greater. CONCLUSIONS:: In critical illness, delaying enteral feeding is associated with a reduction in small intestinal glucose absorption, consistent with the reduction in mucosal integrity after nutrient deprivation evident in animal models. The duration of both mechanical ventilation and length of stay in the intensive care unit are prolonged. These observations support recommendations for "early" enteral nutrition in critically ill patients. |
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Authors:
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Nam Q Nguyen; Laura K Besanko; Carly Burgstad; Max Bellon; Richard H Holloway; Marianne Chapman; Michael Horowitz; Robert J L Fraser |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-15 |
Journal Detail:
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Title: Critical care medicine Volume: - ISSN: 1530-0293 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of Gastroenterology & Hepatology (NQN, CB, RHH), Royal Adelaide Hospital, School of Medicine (NQN, RHH, MC, MH, RJLF), University of Adelaide; Investigation & Procedures Unit (LKB, RJLF), Repatriation General Hospital and Department of Critical Care Services (MC), Royal Adelaide Hospital, Adelaide, South Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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