Document Detail

Delayed diagnosis of primary aldosteronism in patients with autosomal dominant polycystic kidney diseases.
MedLine Citation:
PMID:  22791703     Owner:  NLM     Status:  Publisher    
Hypertension is a frequent early manifestation of autosomal dominant polycystic kidney disease (ADPKD). Several mechanisms can cause hypertension in ADPKD patients, although, primary aldosteronism (PA) as a possible manifestation of hypertension in ADPKD is extremely rare. We retrospectively reviewed the Taiwan Primary Aldosteronism Investigation (TAIPAI) database, which listed a total of 346 patients diagnosed with PA. Of these 346 patients, only three cases of concurrent PA and ADPKD were identified. These patients presented with hypertensive crisis and hypokalemia, and subsequent testing revealed aldosterone-producing adenomas (APAs) that were removed by laparoscopic adrenalectomy. Postoperatively, aldosterone-renin ratios (ARRs) and potassium levels normalized, and blood pressure improved. The diagnosis of PA in ADPKD is extremely challenging because multiple renal cysts can obscure the identification of adrenal adenomas, and ADPKD is associated with hypertension in almost all cases.(1) Because of frequent delays in the diagnosis of PA in ADPKD patients, future prospective studies to screen PA in hypertensive ADPKD patients may be necessary to evaluate the exact prevalence of coexistence of PA and ADPKD.
Chih-Chin Kao; Vin-Cent Wu; Chin-Chi Kuo; Yen-Hung Lin; Ya-Hui Hu; Yao-Chou Tsai; Che-Hsiung Wu; Kwan-Dun Wu
Related Documents :
22512963 - Association of bladder sensation measures and bladder diary in patients with urinary in...
22039473 - Deactivation of the default mode network as a marker of impaired consciousness: an fmri...
9701423 - Pseudomonas aeruginosa bronchopulmonary infection in patients with aids, with emphasis ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-12
Journal Detail:
Title:  Journal of the renin-angiotensin-aldosterone system : JRAAS     Volume:  -     ISSN:  1752-8976     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100971636     Medline TA:  J Renin Angiotensin Aldosterone Syst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
National Taiwan University Hospital, National Taiwan University College of Medicine, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aliskiren improves insulin resistance and ameliorates diabetic renal vascular complications in STZ-i...
Next Document:  Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ov...