| Delayed diagnosis of pediatric Langerhans' cell histiocytosis: case report and retrospective review of pediatric cases seen at Mayo Clinic. | |
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MedLine Citation:
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PMID: 11453455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Langerhans' cell histiocytosis is a disease of the dendritic histiocytes with a wide variety of clinical manifestations. This report describes a boy with Langerhans' cell histiocytosis who presented with primarily neurologic and endocrinologic findings, without pain. The diagnosis of Langerhans' cell histiocytosis was not made until 10 years after symptom onset. The pathology database at Mayo Clinic was searched for cases of Langerhans' cell histiocytosis between 1985 and 1999 under 19 years of age (65 children), and information regarding clinical presentation was abstracted. Database review found a range of 1 day to 156 weeks (mean 13.8 weeks) from symptom onset to diagnosis. No other patients with primarily neurologic symptoms were found. The diagnosis of Langerhans' cell histiocytosis was made significantly sooner after onset if pain was present (chi-square = 19.1, P < .001, two-tailed, phi coefficient 0.54). Our findings indicate that neurologic manifestations of Langerhans' cell histiocytosis are rare, and the combination of diabetes insipidus, ataxia, skin rash, or osseous pain should alert the clinician to the possibility of Langerhans' cell histiocytosis and avoid delayed diagnosis. |
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Authors:
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A A Jarquin-Valdivia; J Buchhalter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 16 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-16 Completed Date: 2001-12-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 535-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Ataxia / etiology Bone and Bones / pathology Child Child, Preschool Diabetes Insipidus / etiology Diagnosis, Differential Diagnostic Errors* Exanthema / etiology Female Histiocytosis, Langerhans-Cell / diagnosis* Humans Infant Male Nervous System Diseases / diagnosis, etiology* Pain / etiology Retrospective Studies |
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