Document Detail

Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor.
MedLine Citation:
PMID:  23118218     Owner:  NLM     Status:  MEDLINE    
KEY POINTS: Targeted deletion of the gene for macrophage migration inhibitory factor (MIF) delays development of chronic lymphocytic leukemia and prolongs survival in mice. MIF recruits leukemia-associated macrophages to spleen or liver.
Nina Reinart; Phuong-Hien Nguyen; Jorge Boucas; Natascha Rosen; Hans-Michael Kvasnicka; Lukas Heukamp; Cornelia Rudolph; Vangica Ristovska; Tanja Velmans; Carolin Mueller; Katrin S Reiners; Elke Pogge von Strandmann; Günter Krause; Manuel Montesinos-Rongen; Brigitte Schlegelberger; Marco Herling; Michael Hallek; Günter Fingerle-Rowson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-01
Journal Detail:
Title:  Blood     Volume:  121     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-03-19     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  812-21     Citation Subset:  AIM; IM    
Department I of Internal Medicine, University Hospital Cologne, and Center for Integrated Oncology Köln-Bonn, Cologne, Germany.
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MeSH Terms
CD8-Positive T-Lymphocytes / immunology*,  pathology
Cell Communication / immunology*
Cell Survival
Feeder Cells
Intramolecular Oxidoreductases / genetics,  immunology*
Leukemia, Lymphocytic, Chronic, B-Cell / genetics,  immunology*,  pathology
Macrophage Migration-Inhibitory Factors / genetics,  immunology*
Macrophages / immunology*,  pathology
Mice, Knockout
Neoplasms, Experimental / genetics,  immunology,  pathology
Tumor Cells, Cultured
Reg. No./Substance:
0/Macrophage Migration-Inhibitory Factors; EC 5.3.-/Intramolecular Oxidoreductases; EC protein, human; EC protein, mouse

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