| Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor. | |
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MedLine Citation:
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PMID: 23118218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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KEY POINTS: Targeted deletion of the gene for macrophage migration inhibitory factor (MIF) delays development of chronic lymphocytic leukemia and prolongs survival in mice. MIF recruits leukemia-associated macrophages to spleen or liver. |
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Authors:
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Nina Reinart; Phuong-Hien Nguyen; Jorge Boucas; Natascha Rosen; Hans-Michael Kvasnicka; Lukas Heukamp; Cornelia Rudolph; Vangica Ristovska; Tanja Velmans; Carolin Mueller; Katrin S Reiners; Elke Pogge von Strandmann; Günter Krause; Manuel Montesinos-Rongen; Brigitte Schlegelberger; Marco Herling; Michael Hallek; Günter Fingerle-Rowson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-11-01 |
Journal Detail:
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Title: Blood Volume: 121 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-02-01 Completed Date: 2013-03-19 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 812-21 Citation Subset: AIM; IM |
Affiliation:
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Department I of Internal Medicine, University Hospital Cologne, and Center for Integrated Oncology Köln-Bonn, Cologne, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals CD8-Positive T-Lymphocytes / immunology*, pathology Cell Communication / immunology* Cell Survival Feeder Cells Humans Intramolecular Oxidoreductases / genetics, immunology* Leukemia, Lymphocytic, Chronic, B-Cell / genetics, immunology*, pathology Macrophage Migration-Inhibitory Factors / genetics, immunology* Macrophages / immunology*, pathology Mice Mice, Knockout Neoplasms, Experimental / genetics, immunology, pathology Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Macrophage Migration-Inhibitory Factors; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.2.1/MIF protein, human; EC 5.3.2.1/Mif protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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