Document Detail


Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor.
MedLine Citation:
PMID:  23118218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
KEY POINTS: Targeted deletion of the gene for macrophage migration inhibitory factor (MIF) delays development of chronic lymphocytic leukemia and prolongs survival in mice. MIF recruits leukemia-associated macrophages to spleen or liver.
Authors:
Nina Reinart; Phuong-Hien Nguyen; Jorge Boucas; Natascha Rosen; Hans-Michael Kvasnicka; Lukas Heukamp; Cornelia Rudolph; Vangica Ristovska; Tanja Velmans; Carolin Mueller; Katrin S Reiners; Elke Pogge von Strandmann; Günter Krause; Manuel Montesinos-Rongen; Brigitte Schlegelberger; Marco Herling; Michael Hallek; Günter Fingerle-Rowson
Related Documents :
23443808 - Effects of mir-19b overexpression on proliferation, differentiation, apoptosis and wnt/...
24117368 - Bimodal immune activation in psoriasis.
23357128 - Inflammation and atherosclerosis: direct versus indirect mechanisms.
23967058 - Intracellular survival and persistence of chlamydia muridarum is determined by macropha...
20723928 - Prostate secretions from men with chronic pelvic pain syndrome inhibit proinflammatory ...
12814628 - In vitro measurement of nuclear permeability changes in apoptosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-01
Journal Detail:
Title:  Blood     Volume:  121     ISSN:  1528-0020     ISO Abbreviation:  Blood     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-03-19     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  812-21     Citation Subset:  AIM; IM    
Affiliation:
Department I of Internal Medicine, University Hospital Cologne, and Center for Integrated Oncology Köln-Bonn, Cologne, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
CD8-Positive T-Lymphocytes / immunology*,  pathology
Cell Communication / immunology*
Cell Survival
Feeder Cells
Humans
Intramolecular Oxidoreductases / genetics,  immunology*
Leukemia, Lymphocytic, Chronic, B-Cell / genetics,  immunology*,  pathology
Macrophage Migration-Inhibitory Factors / genetics,  immunology*
Macrophages / immunology*,  pathology
Mice
Mice, Knockout
Neoplasms, Experimental / genetics,  immunology,  pathology
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Macrophage Migration-Inhibitory Factors; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.2.1/MIF protein, human; EC 5.3.2.1/Mif protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The triumph of good over evil: protection by the sickle gene against malaria.
Next Document:  The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.