Document Detail

Delayed decompressive craniectomy improves the long-term outcomes in hypertensive rats with space-occupying cerebral infarction.
MedLine Citation:
PMID:  17701109     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: No experimental data has been published on the long-term effects of decompressive craniotomy in hypertensive rats with space-occupying cerebral infarction. The aim of the present study was to investigate the efficacy of decompressive craniectomy in a middle cerebral artery occlusion (MCAO) model of hypertensive rats in a prolonged period. METHODS: Totally 92 stroke-prone renovascular hypertensive rats (RHRSP) were subjected to left MCAO by an endovascular occlusion technique. The decompressive craniectomy was performed on 26 RHRSP at 1 and 24 h after MCAO, respectively. Infarct volume, neurological performance, and mortality were evaluated at 1, 2, 4, and 8 weeks after MCAO. RESULTS: The mortality was reduced from 52.5% in controls to 7.7% and 23.1% in the rats underwent craniectomy at 1 and 24 h after MCAO, respectively (P < 0.05, respectively). All of the treated rats presented smaller infarct volume from 1 week to 8 weeks and better neurological performance at 4-8 weeks after MCAO compared to the controls (P < 0.05, respectively). The craniectomy at early stage was more effective than that at late stage in reducing infarct volume and improving neurological performances at 1 and 2 weeks (P < 0.05, respectively). However, there was no significant difference in infarct volume and neurological scores between the treated groups of rats at 4 and 8 weeks after MCAO (P > 0.05). CONCLUSIONS: Although the early craniectomy is more effective than delayed craniectomy in improving short-term outcome, the latter has the similar beneficial effects as early craniectomy on long-term outcome in hypertensive rats with space-occupying cerebral infarction.
Zhan Zhao; Jian Yu; Songjie Liao; Li Xiong; Zhijian Liang; Li Ling; Fang Wang; Qinghua Hou; Wenliang Zhou; Zhong Pei; Jinsheng Zeng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurocritical care     Volume:  7     ISSN:  1541-6933     ISO Abbreviation:  Neurocrit Care     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
Department of Neurology and Stroke Centre, the First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou, 510080, PR China.
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MeSH Terms
Craniotomy / methods*
Decompression, Surgical / methods*
Disease Models, Animal
Hypertension, Renovascular / complications*
Infarction, Middle Cerebral Artery / complications*,  pathology,  surgery*
Rats, Sprague-Dawley
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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