Document Detail

Delayed cyanide poisoning following acetonitrile ingestion.
MedLine Citation:
PMID:  9196706     Owner:  NLM     Status:  MEDLINE    
Acetonitrile (methyl cyanide) is a common industrial organic solvent but is a rare cause of poisoning. We report the first recorded UK case. Acetonitrile is slowly converted to cyanide, resulting in delayed toxicity. We describe a case of deliberate self-poisoning by a 39-year-old woman resulting in cyanide poisoning 11 hours later which was successfully treated by repeated boluses of sodium nitrite and thiosulphate. The half-life of conversion of acetonitrile was 40 hours and harmful blood cyanide levels persisted for over 24 hours after ingestion. Departments treating or advising in cases of poisoning need to be aware of the delayed toxicity of acetonitrile. Monitoring in an intensive care unit of cases of acetonitrile poisoning should continue for 24-48 hours.
M Mueller; C Borland
Related Documents :
513426 - Acute poisoning from over-the-counter sleep preparations.
18821486 - Four-year experience with methotrexate exposures.
7897756 - Whole bowel irrigation after delayed release fenfluramine overdose.
2811676 - Management of dapsone poisoning complicated by methaemoglobinaemia.
17845176 - Isotretinoin-induced agranulocytosis.
871046 - Small vesicovaginal fistula.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  73     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-09     Completed Date:  1997-07-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-300     Citation Subset:  IM    
Hinchingbrooke Hospital, Huntingdon, Cambridgeshire, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetonitriles / metabolism,  poisoning*
Antidotes / therapeutic use
Cyanides / poisoning*
Poisoning / drug therapy
Sodium Nitrite / therapeutic use
Suicide, Attempted
Thiosulfates / therapeutic use
Time Factors
Reg. No./Substance:
0/Acetonitriles; 0/Antidotes; 0/Cyanides; 0/Thiosulfates; 7632-00-0/Sodium Nitrite; 7772-98-7/sodium thiosulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Barium peritonitis: a rare complication of upper gastrointestinal contrast investigation.
Next Document:  Respiratory arrest during dipyridamole stress testing.