Document Detail


Delayed cuticular penetration and enhanced metabolism of deltamethrin in pyrethroid-resistant strains of Helicoverpa armigera from China and Pakistan.
MedLine Citation:
PMID:  16649192     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The penetration and metabolism of [14C]deltamethrin was studied in susceptible and resistant Chinese and Pakistani strains of Helicoverpa armigera (Hübner), which were resistant to deltamethrin by 330- and 670-fold, respectively. The penetration of deltamethrin into resistant individuals was significantly slower than into susceptible individuals over a 24-h period. The time taken for 50% penetration of the applied deltamethrin was 1 h for the susceptible strain and 6 h for both of the resistant strains. The internal radioactivity was reduced by the larvae of resistant strains much faster than by the susceptible larvae. After 48 h, 40% of the penetrated deltamethrin was still inside the larvae of the susceptible strain, in comparison with 1.5-5% in the Pakistani strain and 8-14% in the Chinese strain. Both of the resistant strains produced methanol-soluble and water-soluble metabolites, but the susceptible strain produced methanol-soluble metabolites only. By 12, 24 and 48 h after dosing, the amount of methanol-soluble metabolites excreted by the resistant strains was almost double that of the susceptible strain. Both of the resistant strains also excreted 5-7% of the penetrated dose as a water-soluble metabolite after 48 h. In comparison with the Chinese strain, the Pakistani strain exhibited slower penetration, lower internal content and faster excretion of deltamethrin, which correlated with the higher resistance of the Pakistani strain. These findings show that the resistant Pakistani and Chinese strains of H. armigera possess mechanisms of reduced cuticular penetration and enhanced metabolism of deltamethrin and perhaps other pyrethroids.
Authors:
Mushtaq Ahmad; Ian Denholm; Richard H Bromilow
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pest management science     Volume:  62     ISSN:  1526-498X     ISO Abbreviation:  Pest Manag. Sci.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-28     Completed Date:  2006-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898744     Medline TA:  Pest Manag Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  805-10     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Society of Chemical Industry.
Affiliation:
Central Cotton Research Institute, Multan, Pakistan. mush_a@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Radioisotopes / analysis
China
Insecticide Resistance
Insecticides / pharmacokinetics*
Larva / metabolism,  physiology
Moths / metabolism*,  physiology
Nitriles / pharmacokinetics*
Pakistan
Pyrethrins / pharmacokinetics*,  pharmacology
Solubility
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Insecticides; 0/Nitriles; 0/Pyrethrins; 52820-00-5/decamethrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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