| Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis. | |
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MedLine Citation:
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PMID: 11948059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVES: To evaluate new and already known biological markers of activity in patients with sarcoidosis. DESIGN: A 10-year prospective clinical evaluation, including a battery of delayed cutaneous hypersensitivity tests (DCHTs) and other markers of activity. SETTING: Outpatient department of a university teaching hospital. PATIENTS: Forty patients with biopsy-proven sarcoidosis were prospectively evaluated every 6 months. In this study, only the visits that fulfilled the situation of active period (AcP) or of asymptomatic period (AsP) were taken into account. Twenty-one visits were considered to be in the AcP, and 26 were considered to be in the AsP. Seven patients were studied both in the AcP and the AsP. INTERVENTIONS: DCHTs and blood sample extraction every 6 months. MEASUREMENTS AND RESULTS: The mean diameter of the cutaneous wheal for each antigen (AG) was lower in the AcP group than in the AsP group (candidine, p < 0.0001; tuberculin, p < 0.0009; trichophytin, p < 0.02; streptokinase-streptodornase, p < 0.001). Also, the mean (+/- SD) diameter for the four AGs taken together was lower in the AcP group (2.3 +/- 4.2 mm) than in the AsP group (16.8 +/- 9.3 mm; p < 0.0001). The mean serum angiotensin-converting enzyme (S-ACE) value was higher in the AcP group than in the AsP group (p < 0.02). A low lymphocyte count and a percentage of the lymphocyte count (< 20%) also were detected more frequently in the AcP group than in the AsP group (p < 0.02 and p < 0.0001, respectively). CONCLUSIONS: DCHTs appear to be a simple, reliable, and easily performed marker of inflammatory activity in sarcoidosis patients. Furthermore, serum total and differential lymphocyte count and the S-ACE level proved to be useful inflammatory markers in this study. |
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Authors:
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Ferran Morell; Gur Levy; Ramon Orriols; Jaume Ferrer; Javier De Gracia; Gabriel Sampol |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chest Volume: 121 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-11 Completed Date: 2002-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1239-44 Citation Subset: AIM; IM |
Affiliation:
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Servei de Pneumologia, Hospital General Vall d'Hebron, Barcelona, Spain. fmorell@hg.vhebron.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Follow-Up Studies Forced Expiratory Volume / physiology Humans Hypersensitivity, Delayed / diagnosis*, immunology Intradermal Tests* Lymphopenia / diagnosis*, immunology Male Middle Aged Predictive Value of Tests Prospective Studies Sarcoidosis, Pulmonary / diagnosis*, immunology Skin / immunology Vital Capacity / physiology |
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