Document Detail

Delayed cutaneous hypersensitivity: epidemiologic factors affecting and usefulness in predicting diarrheal incidence in young Peruvian children.
MedLine Citation:
PMID:  2785674     Owner:  NLM     Status:  MEDLINE    
Cell-mediated immunity, as assessed by delayed cutaneous hypersensitivity, can be diminished by malnutrition and viral infections. In turn, decreased immune functioning might lead to more frequent or more severe infectious diseases. Delayed cutaneous hypersensitivity was assessed in young Peruvian children by simultaneous application of seven standardized antigens and a negative control (Multitest CMI). Response to tuberculin was frequent and was higher in children vaccinated with Bacillus Calmette-Guérin, response to tetanus or diphtheria toxoids was also good, especially in children who had received at least two doses of diphtheria-tetanus toxoids-pertussis vaccine. Two summary assessments, the number of positive responses and the sum of indurations of all positive responses provided useful measures of delayed cutaneous hypersensitivity. Responsiveness, as assessed by these summary measures, was inversely related to the incidence of diarrhea, identified by household surveillance for the 6 months after the skin test. Undernutrition, as assessed by weight for age or length for age, was also a significant determinant of the incidence of diarrhea, but not the duration of episodes, in this group of study children. Depressed cell-mediated immunity and malnutrition may be important risk factors for diarrhea in developing country children.
R E Black; C F Lanata; F Lazo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  8     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-15     Completed Date:  1989-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  210-5     Citation Subset:  IM    
Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD.
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MeSH Terms
Child, Preschool
Cohort Studies
Diarrhea, Infantile / epidemiology*,  etiology,  immunology
Hypersensitivity, Delayed / diagnosis*
Immunity, Cellular
Infant, Newborn
Nutrition Disorders / complications*,  diagnosis,  immunology
Prospective Studies
Risk Factors
Skin Tests*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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