Document Detail

Delayed cervicobulbar neuronopathy and myokymia after head and neck radiotherapy for nasopharyngeal carcinoma: a case report.
MedLine Citation:
PMID:  21321494     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: : Delayed progressive cervicobulbar palsy with secondary lingual, facial, and neck myokymia after radiation therapy to the head and neck is a known but rare event with few reported case descriptions.
CASE PRESENTATION: : We report a case with a video description of a young Asian woman who developed progressive dysarthria and dysphagia after approximately 1 year after radiation treatment for nasopharyngeal carcinoma. Her symptoms, clinical, and electromyographic findings are discussed and were felt to be secondary to a cervicobulbar neuronopathy secondary to the previous radiation she received. A brief literature review was performed and pathophysiological mechanisms and treatment options are discussed.
CONCLUSION: : Delayed progressive cervicobulbar neuronopathy with myokymia is an uncommon complication of radiotherapy for nasopharyngeal carcinoma. Clinicians should be aware of this entity to prevent misdiagnosis with other neuromuscular and nonneuromuscular diseases.
Richard A Rison; Said R Beydoun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuromuscular disease     Volume:  12     ISSN:  1537-1611     ISO Abbreviation:  J Clin Neuromuscul Dis     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887391     Medline TA:  J Clin Neuromuscul Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
From the *Department of Neurology, University of Southern California, Keck School of Medicine, and Presbyterian Intercommunity Hospital Stroke Center, Whittier, CA; and †Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles County Medical Center, Los Angeles, CA.
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