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Delayed cerebral radiation necrosis following treatment for a plasmacytoma of the skull.
MedLine Citation:
PMID:  21125009     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cerebral radiation necrosis is a relatively common complication of radiation therapy for intracranial malignancies which can also rarely be encountered after radiation of extracranial lesions of the head and neck. We present the first reported case of cerebral radiation necrosis in a patient who underwent radiation therapy for a plasmacytoma of the skull.
CASE DESCRIPTION: A 68-year-old male with multiple myeloma presented with an enhancing right frontal mass, 8 years after receiving radiation therapy for a plasmacytoma of the left frontal skull. The patient underwent a diagnostic and therapeutic craniotomy for a presumed neoplastic lesion. The pathologic diagnosis made in this case was delayed radiation necrosis. The patient was followed for over a year during which this process continued to evolve before the ultimate resolution of his clinical symptoms and radiographic abnormality.
CONCLUSION: This case highlights the importance of considering radiation necrosis in the differential diagnosis of any patient with an intracranial mass and a history of radiation for an extracranial head and neck malignancy, regardless of timing and laterality. This case also provides unique insights into the ongoing debate regarding the role of the aberrant immune response in the pathogenesis of delayed cerebral radiation necrosis.
Authors:
Lola B Chambless; Federica B Angel; Ty W Abel; Fen Xia; Kyle D Weaver
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Publication Detail:
Type:  Journal Article     Date:  2010-10-25
Journal Detail:
Title:  Surgical neurology international     Volume:  1     ISSN:  2152-7806     ISO Abbreviation:  Surg Neurol Int     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101535836     Medline TA:  Surg Neurol Int     Country:  India    
Other Details:
Languages:  eng     Pagination:  65     Citation Subset:  -    
Affiliation:
Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
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