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Delayed and asynchronous ganglionic maturation during cephalopod neurogenesis as evidenced by Sof-elav1 expression in embryos of Sepia officinalis (Mollusca, Cephalopoda).
MedLine Citation:
PMID:  23047428     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Among the Lophotrochozoa, centralization of the nervous system reaches an exceptional level of complexity in cephalopods, where the typical molluscan ganglia become highly developed and fuse into hierarchized lobes. It is known that ganglionic primordia initially emerge early and simultaneously during cephalopod embryogenesis but no data exist on the process of neuron differentiation in this group. We searched for members of the elav/hu family in the cuttlefish Sepia officinalis, since they are one of the first genetic markers of post-mitotic neural cells. Two paralogs have been identified and the expression of the most neural-specific gene, Sof-elav1, has been characterized during embryogenesis. Sof-elav1 is expressed in all ganglia at one time of the development, which provides the first genetic map of neurogenesis in a cephalopod. Our results unexpectedly revealed that Sof-elav1 expression is not similar and not coordinated in all the prospective ganglia. Both palliovisceral ganglia show extensive Sof-elav1 expression soon after emergence, showing that most of their cells differentiate into neurons at an early stage. On the contrary, other ganglia, and especially both cerebral ganglia that contribute to the main parts of the brain learning centres, show a late extensive Sof-elav1 expression. These delayed expressions in ganglia suggest that most ganglionic cells retain their proliferative capacities and postpone differentiation. In other molluscs, where a larval nervous system predates the development of the definitive adult nervous system, cerebral ganglia are among the first to mature. Thus, such a difference may constitute a cue in understanding the peculiar brain evolution in cephalopods. J. Comp. Neurol., 2012. © 2012 Wiley Periodicals, Inc.
Authors:
A Buresi; E Canali; L Bonnaud; S Baratte
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  -     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Museum National d'Histoire Naturelle (MNHN), DMPA, UMR Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), MNHN CNRS 7208, IRD 207, UPMC, 55 rue Buffon, CP51 75005 Paris, France; Université Paris Pierre et Marie Curie - Paris 6, Paris, France. buresi@mnhn.fr.
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