Document Detail


Delayed appearance of Chlamydia trachomatis infections acquired at birth.
MedLine Citation:
PMID:  3696827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the delay in detectability of Chlamydia trachomatis infections acquired at birth, we serially evaluated 120 infants born vaginally to infected women. Specimens for isolation of Chlamydia were taken from several anatomic sites. Results were analyzed for the age and site of the initial positive culture from each infant. Of 112 infants tested in the first month of life, 22% were culture-positive in the conjunctiva and 25% were positive in the pharynx. Initial positive rectal and vaginal cultures were obtained only in the third and fourth months of life, and all initial vaginal cultures were associated with positive rectal cultures. The latency of C. trachomatis in infants exposed at birth is often more than 1 month and can be longer than 97 days. This latency might be caused by suppression of the growth of the organism by antibodies acquired in utero.
Authors:
T A Bell; W E Stamm; C C Kuo; S P Wang; K K Holmes; J T Grayston
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  6     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-01-27     Completed Date:  1988-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  928-31     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, School of Medicine, University of Washington, Seattle.
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MeSH Terms
Descriptor/Qualifier:
Antibody Formation
Chlamydia Infections / congenital*,  immunology
Chlamydia trachomatis / isolation & purification
Conjunctiva / microbiology
Female
Humans
Infant
Infant, Newborn
Male
Pharynx / microbiology
Prospective Studies
Time Factors
Vagina / microbiology
Grant Support
ID/Acronym/Agency:
AI-12192/AI/NIAID NIH HHS; AI-16222/AI/NIAID NIH HHS; EY-00219/EY/NEI NIH HHS
Comments/Corrections
Erratum In:
Pediatr Infect Dis J 1988 Apr;7(4):303

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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