Document Detail

Delayed anaphylaxis to red meat masquerading as idiopathic anaphylaxis.
MedLine Citation:
PMID:  24811014     Owner:  NLM     Status:  In-Data-Review    
Anaphylaxis is traditionally recognized as a rapidly developing combination of symptoms that often includes hives and hypotension or respiratory symptoms. Furthermore, when a specific cause is identified, exposure to this cause is usually noted to have occurred within minutes to 2 hours before the onset of symptoms. This case is of a 79-year-old woman who developed a severe episode of anaphylaxis 3 hours after eating pork. Before 2012, she had not experienced any symptoms after ingestion of meat products. Delayed anaphylaxis to mammalian meat has many contrasting features to immediate food-induced anaphylaxis. The relevant IgE antibody is specific for the oligosaccharide galactose-alpha-1,3-galactose, a blood group substance of nonprimate mammals. There is evidence from Australia, Sweden, and the United States that the primary cause of this IgE antibody response is tick bites. These bites characteristically itch for 10 days or more. Diagnosis can be made by the presence of specific IgE to beef, pork, lamb, and milk, and the lack of IgE to chicken, turkey, and fish. Skin prick tests (but not intradermal tests) generally are negative. Management of these cases, now common across the southeastern United States, consists of education combined with avoidance of both ingestion of red meat and further tick bites.
Anubha Tripathi; Scott P Commins; Peter W Heymann; Thomas A E Platts-Mills
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of allergy and clinical immunology. In practice     Volume:  2     ISSN:  2213-2198     ISO Abbreviation:  J Allergy Clin Immunol Pract     Publication Date:    2014 May-Jun
Date Detail:
Created Date:  2014-05-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101597220     Medline TA:  J Allergy Clin Immunol Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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