| Delayed adverse vascular events after splenectomy in hereditary spherocytosis. | |
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MedLine Citation:
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PMID: 18485083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is probable that the variety and frequency of delayed adverse vascular events after splenectomy are underappreciated. Splenectomy is performed for a wide variety of conditions, and delayed postsplenectomy hazards are not often studied. OBJECTIVE: To estimate the relative risk of adverse vascular events in members of hereditary spherocytosis families who have or have not had a splenectomy. METHODS: Members of families in which hereditary spherocytosis exists were systematically questioned about adverse vascular events. RESULTS: The cumulative incidence of arterial and venous events at age 70 years was greater in persons who had undergone a splenectomy for spherocytosis (arterial, 22% females, 32% males; venous, 20% females, 19% males) than in affected persons who did not undergo splenectomy (arterial, 3% females, 2% males; venous, 6% females, 4% males) or non-affected family members (arterial, 10% females, 17% males; venous, 4% females, 12% males). Affected subjects who undergo splenectomy are at greatly increased risk of arterial events as compared to affected subjects who do not undergo splenectomy [arterial, hazard ratio (HR) 7.2, 95% confidence interval (CI) 2.8-17.2; venous, HR 3.3, 95% CI 1.1-9.8]. CONCLUSION: There is a significant, long-lasting, increased risk of adverse arterial and venous thromboembolic events after splenectomy performed for hereditary spherocytosis. A review of the literature indicates that this is also true when splenectomy is performed for several other indications. |
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Authors:
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R F Schilling; R E Gangnon; M I Traver |
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Publication Detail:
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Type: Journal Article Date: 2008-05-15 |
Journal Detail:
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Title: Journal of thrombosis and haemostasis : JTH Volume: 6 ISSN: 1538-7836 ISO Abbreviation: J. Thromb. Haemost. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-27 Completed Date: 2008-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: England |
Other Details:
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Languages: eng Pagination: 1289-95 Citation Subset: IM |
Affiliation:
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Department of Medicine, Emeritus, University of Wisconsin-Madison, Madison, WI, USA. rfsmd@medicine.wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Female Humans Hypertension, Pulmonary / etiology Male Middle Aged Osteonecrosis / etiology Postoperative Complications / etiology* Priapism / etiology Proportional Hazards Models Prospective Studies Pulmonary Embolism / etiology Risk Factors Spherocytosis, Hereditary / complications*, surgery* Splenectomy / adverse effects* Time Factors Vascular Diseases / etiology* Venous Thromboembolism / etiology |
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