| Delayed left ventricular untwisting in hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 19815387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Almost all patients with hypertrophic cardiomyopathy (HCM) have some degree of left ventricular (LV) diastolic dysfunction. Nevertheless, the pathophysiology remains incompletely characterized. Conceptually, an ideal therapeutic agent should target the underlying mechanisms that cause LV diastolic dysfunction. Assessment of diastolic LV untwisting could potentially be helpful to gain insight into the mechanism of diastolic dysfunction. The purpose of this study was to investigate LV untwisting in patients with HCM and control subjects. METHODS: LV untwisting parameters were assessed using speckle-tracking echocardiography in 75 consecutive patients with HCM and compared with those from 75 healthy control subjects. RESULTS: Untwisting at 5%, 10%, and 15% of diastole was lower in patients with HCM (all P values < .001) compared with control subjects. Peak diastolic untwisting velocity (-92 +/- 32 degrees/s vs -104 +/- 39 degrees/s, P < .05) and untwisting rate from peak systolic twist to mitral valve opening (MVO) (-37 +/- 20 degrees/s vs -46 +/- 22 degrees/s, P < .01) were lower, while the for diastolic duration normalized time-to-peak diastolic untwisting velocity (17 +/- 9% vs 13 +/- 9%, P < .05) was higher in patients with HCM. Untwisting rate from peak systolic twist to MVO was negatively correlated with the E/A ratio (R(2) = 0.15, P < .01). Peak diastolic untwisting velocity and untwisting rate from peak systolic twist to MVO were increased in mild but decreased in moderate and severe diastolic dysfunction compared with control subjects. CONCLUSION: LV untwisting is delayed in HCM, which probably significantly contributes to diastolic dysfunction. |
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Authors:
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Bas M van Dalen; Floris Kauer; Michelle Michels; Osama I I Soliman; Wim B Vletter; Heleen B van der Zwaan; Folkert J ten Cate; Marcel L Geleijnse |
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Publication Detail:
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Type: Journal Article Date: 2009-10-07 |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 22 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 1320-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiomyopathy, Hypertrophic / complications*, ultrasonography* Echocardiography / methods* Female Heart Ventricles / ultrasonography* Humans Male Reproducibility of Results Sensitivity and Specificity Ventricular Dysfunction, Left / complications*, ultrasonography* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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