Document Detail

Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats.
MedLine Citation:
PMID:  22354242     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Anesthesia given to immature rodents causes cognitive decline, raising the possibility that the same might be true for millions of children undergoing surgical procedures under general anesthesia each year. We tested the hypothesis that anesthesia-induced cognitive decline in rats is treatable. We also tested if anesthesia-induced cognitive decline is aggravated by tissue injury.
METHODS: Seven-day old rats underwent sevoflurane anesthesia (1 minimum alveolar concentration, 4 h) with or without tail clamping. At 4 weeks, rats were randomized to environmental enrichment or normal housing. At 8 weeks rats underwent neurocognitive testing, which consisted of fear conditioning, spatial reference memory, and water maze-based memory consolidation tests, and interrogated working memory, short-term memory, and early long-term memory.
RESULTS: Sevoflurane-treated rats had a greater escape latency when the delay between memory acquisition and memory retrieval was increased from 1 min to 1 h, indicating that short-term memory was impaired. Delayed environmental enrichment reversed the effects of sevoflurane on short-term memory and generally improved many tested aspects of cognitive function, both in sevoflurane-treated and control animals. The performance of tail-clamped rats did not differ from those rats receiving anesthesia alone.
CONCLUSION: Sevoflurane-induced cognitive decline in rats is treatable. Delayed environmental enrichment rescued the sevoflurane-induced impairment in short-term memory. Tissue injury did not worsen the anesthesia-induced memory impairment. These findings may have relevance to neonatal and pediatric anesthesia.
Jennifer Shih; Laura D V May; Heidi E Gonzalez; Elaine W Lee; Rehan S Alvi; Jeffrey W Sall; Vinuta Rau; Philip E Bickler; Gopal R Lalchandani; Marianna Yusupova; Elliott Woodward; Heejae Kang; Alan J Wilk; Colleen M Carlston; Mortay V Mendoza; Jeremy N Guggenheim; Maximilian Schaefer; Allison M Rowe; Greg Stratmann
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  116     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-22     Completed Date:  2012-04-10     Revised Date:  2014-08-28    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  586-602     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Animals, Newborn
Housing, Animal*
Maze Learning / drug effects,  physiology
Memory Disorders / chemically induced*,  physiopathology,  therapy*
Methyl Ethers / toxicity*
Random Allocation
Rats, Sprague-Dawley
Time Factors
Grant Support
Reg. No./Substance:
0/Methyl Ethers; 28523-86-6/sevoflurane
Comment In:
Anesthesiology. 2012 Mar;116(3):507-9   [PMID:  22258021 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exceptionally stable fluorous emulsions for the intravenous delivery of volatile general anesthetics...
Next Document:  Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: an unblinded...