| Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. | |
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MedLine Citation:
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PMID: 22354242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Anesthesia given to immature rodents causes cognitive decline, raising the possibility that the same might be true for millions of children undergoing surgical procedures under general anesthesia each year. We tested the hypothesis that anesthesia-induced cognitive decline in rats is treatable. We also tested if anesthesia-induced cognitive decline is aggravated by tissue injury. METHODS: Seven-day old rats underwent sevoflurane anesthesia (1 minimum alveolar concentration, 4 h) with or without tail clamping. At 4 weeks, rats were randomized to environmental enrichment or normal housing. At 8 weeks rats underwent neurocognitive testing, which consisted of fear conditioning, spatial reference memory, and water maze-based memory consolidation tests, and interrogated working memory, short-term memory, and early long-term memory. RESULTS: Sevoflurane-treated rats had a greater escape latency when the delay between memory acquisition and memory retrieval was increased from 1 min to 1 h, indicating that short-term memory was impaired. Delayed environmental enrichment reversed the effects of sevoflurane on short-term memory and generally improved many tested aspects of cognitive function, both in sevoflurane-treated and control animals. The performance of tail-clamped rats did not differ from those rats receiving anesthesia alone. CONCLUSION: Sevoflurane-induced cognitive decline in rats is treatable. Delayed environmental enrichment rescued the sevoflurane-induced impairment in short-term memory. Tissue injury did not worsen the anesthesia-induced memory impairment. These findings may have relevance to neonatal and pediatric anesthesia. |
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Authors:
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Jennifer Shih; Laura D V May; Heidi E Gonzalez; Elaine W Lee; Rehan S Alvi; Jeffrey W Sall; Vinuta Rau; Philip E Bickler; Gopal R Lalchandani; Marianna Yusupova; Elliott Woodward; Heejae Kang; Alan J Wilk; Colleen M Carlston; Mortay V Mendoza; Jeremy N Guggenheim; Maximilian Schaefer; Allison M Rowe; Greg Stratmann |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 116 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-22 Completed Date: 2012-04-10 Revised Date: 2012-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 586-602 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia, University of California San Francisco, San Francisco, California 94143, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Animals, Newborn Housing, Animal* Male Maze Learning / drug effects, physiology Memory Disorders / chemically induced*, physiopathology, therapy* Methyl Ethers / toxicity* Random Allocation Rats Rats, Sprague-Dawley Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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K08 GM086511/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methyl Ethers; 28523-86-6/sevoflurane |
| Comments/Corrections | |
Comment In:
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Anesthesiology. 2012 Mar;116(3):507-9
[PMID:
22258021
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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