Document Detail

Delayed CNS maturation in iron-deficient anaemic infants.
MedLine Citation:
PMID:  18510805     Owner:  NLM     Status:  MEDLINE    
Direct evidence of CNS developmental alterations in iron-deficient anaemic (IDA) infants was obtained. Twenty 3-15-month-old IDA and 20 non-IDA infants (age and gender matched), healthy in every other respect, were studied. Complete blood and iron kinetics tests determined an IDA status. Psychomotor development was assessed through the test of Rogers and co-workers [Rogers SJ, Donovan CM, D'Eugenio D, Brown SL, Whiteside E, Moersch MS, Schafer DS. (eds) Developmental Programming for Infants and Young Children, Vol 2. University of Michigan Press, 1981] and under the 10-20 International System qEEG was performed (sleep/stage II). A Pearson's correlation test was applied between haematological, psychomotor and broad band EEG variables, and through ANOVA psychomotor and AP means were compared. IDA infants showed lower scores in cognition, fine motor and social/emotional areas, higher delta/theta and lower alpha power. Most correlations between haematological/psychological variables were positive. Delta/theta correlations were negative with self-care/gross and motor items while alpha/beta AP showed positive correlations with psychomotor and haematological variables. A clear association was found between EEG alterations and a low haematological/iron profile leading to a delayed psychomotor development.
Rosalva Ayala; Gloria A Otero; Rosario Porcayo Mercado; F Bernardo Pliego-Rivero
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  11     ISSN:  1476-8305     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-30     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca, México.
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MeSH Terms
Anemia, Iron-Deficiency / complications*,  physiopathology
Central Nervous System / growth & development*
Hemoglobins / analysis
Infant Nutritional Physiological Phenomena
Motor Activity
Psychomotor Disorders / etiology
Reg. No./Substance:

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