Document Detail


Delayed anaphylaxis to red meat in patients with IgE specific for galactose alpha-1,3-galactose (alpha-gal).
MedLine Citation:
PMID:  23054628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal. In instances where the triggering allergen is not known, establishing the etiology of anaphylaxis is pivotal to long-term risk management. Our recent work has identified a novel IgE antibody (Ab) response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal), that has been associated with two distinct forms of anaphylaxis: (1) immediate onset anaphylaxis during first exposure to intravenous cetuximab, and (2) delayed onset anaphylaxis 3-6 h after ingestion of mammalian food products (e.g., beef and pork). The results of our studies strongly suggest that tick bites are a cause, if not the only significant cause, of IgE Ab responses to alpha-gal in the southern, eastern and central United States. Patients with IgE Ab to alpha-gal continue to emerge and, increasingly, these cases involve children. This IgE Ab response cross-reacts with cat and dog but does not appear to pose a risk for asthma; however, it may impair diagnostic testing in some situations.
Authors:
Scott P Commins; Thomas A E Platts-Mills
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current allergy and asthma reports     Volume:  13     ISSN:  1534-6315     ISO Abbreviation:  Curr Allergy Asthma Rep     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-04-17     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  101096440     Medline TA:  Curr Allergy Asthma Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology*
Anaphylaxis / etiology*,  immunology
Animals
Antibodies, Monoclonal / adverse effects
Antibodies, Monoclonal, Humanized
Asthma / immunology
Cross Reactions / immunology
Disaccharides / immunology*
Epitopes / immunology
Food Hypersensitivity / etiology*,  immunology
Humans
Immunoglobulin E / blood*
Insect Bites and Stings / immunology
Meat / adverse effects*
Ticks
Grant Support
ID/Acronym/Agency:
AI-20565/AI/NIAID NIH HHS; K08 AI085190/AI/NIAID NIH HHS; K08-AI-1085190/AI/NIAID NIH HHS; R01 AI020565/AI/NIAID NIH HHS; R21 AI087985/AI/NIAID NIH HHS; R21-AI-087985/AI/NIAID NIH HHS; T32 AI007496/AI/NIAID NIH HHS; U19-AI-070364/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Disaccharides; 0/Epitopes; 13168-24-6/galactosyl-(1-3)galactose; 37341-29-0/Immunoglobulin E; PQX0D8J21J/cetuximab
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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