Document Detail

Delay of tooth eruption in null mice devoid of the type I IL-1R gene.
MedLine Citation:
PMID:  10946764     Owner:  NLM     Status:  MEDLINE    
Interleukin-one alpha (IL-1alpha) is located in the stellate reticulum and its receptor, type I IL-1R (IL-1R), is present in the adjacent dental follicle. IL-1alpha may play a role in initiating tooth eruption because of its ability to enhance the gene expression in the dental follicle of putative tooth eruption molecules colony-stimulating factor-one (CSF-1). monocyte chemotactic protein-1 (MCP-1), and nuclear factor kappa B (NFkappa-B). To directly examine the effect of IL-1alpha and IL-1R on tooth eruption, we observed the times of tooth eruption in null mice devoid of the type I IL-1R gene. The results showed that the time of eruption in the null mice was delayed by 2 d for the first mandibular molar and 1 d for incisors as compared to wild type controls. Reverse transcription-polymerase chain reaction (RT-PCR) techniques confirmed the absence of the IL-1R gene in the null mice, but the genes for CSF-1 and NFkappaB were still expressed. Thus, a molecule(s) other than IL-1alpha also may enhance the expression of CSF- and NFkappaB in the dental follicle. Because there is a slight delay of tooth eruption in IL-1R null mice, IL-1alpha may normally play a role in eruption. However, eruption eventually can occur without the signaling from IL-1alpha.
H Huang; G E Wise
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of oral sciences     Volume:  108     ISSN:  0909-8836     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-06     Completed Date:  2000-12-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  D; IM    
Department of Veterinary Anatomy and Cell Biology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803-8408, USA.
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MeSH Terms
Enhancer Elements, Genetic / physiology
Interleukin-1 / physiology*
Macrophage Colony-Stimulating Factor / physiology
Mice, Knockout
NF-kappa B / physiology
Receptors, Interleukin-1 / genetics,  physiology*
Reverse Transcriptase Polymerase Chain Reaction
Tooth Eruption / genetics*,  physiology*
Grant Support
Reg. No./Substance:
0/Interleukin-1; 0/NF-kappa B; 0/Receptors, Interleukin-1; 81627-83-0/Macrophage Colony-Stimulating Factor

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