Document Detail

Delay of preterm delivery in sheep by omega-3 long-chain polyunsaturates.
MedLine Citation:
PMID:  10026118     Owner:  NLM     Status:  MEDLINE    
A positive correlation has been shown between dietary intake of long-chain omega-3 fatty acids in late pregnancy and gestation length in pregnant women and experimental animals. To determine whether omega-3 fatty acids have an effect on preterm labor in sheep, a fish oil concentrate emulsion was continuously infused to six pregnant ewes from 124 days gestational age. At 125 days, betamethasone was administered to the fetus to produce preterm labor. Both the onset of labor and the time of delivery were delayed by the fish oil emulsion. Two of the omega-3-infused ewes reverted from contractions to nonlabor, an effect never previously observed for experimental glucocorticoid-induced preterm labor in sheep. Maternal plasma estradiol and maternal and fetal prostaglandin E2 rose in control ewes but not in those infused with omega-3 fatty acid. The ability of omega-3 fatty acids to delay premature delivery in sheep indicates their possible use as tocolytics in humans. Premature labor is the major cause of neonatal death and long-term disability, and these studies present information that may lead to a novel therapeutic regimen for the prevention of preterm delivery in human pregnancy.
M Baguma-Nibasheka; J T Brenna; P W Nathanielsz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of reproduction     Volume:  60     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-03-11     Completed Date:  1999-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  698-701     Citation Subset:  IM    
Laboratory for Pregnancy and Newborn Research, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, USA.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Dinoprostone / blood
Estradiol / blood
Fat Emulsions, Intravenous
Fatty Acids, Omega-3 / administration & dosage,  therapeutic use*
Fetal Blood / metabolism
Fish Oils / administration & dosage
Gestational Age
Hydrocortisone / blood
Obstetric Labor, Premature / chemically induced,  drug therapy*
Progesterone / blood
Grant Support
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids, Omega-3; 0/Fish Oils; 363-24-6/Dinoprostone; 378-44-9/Betamethasone; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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