Document Detail


Delay of preterm delivery in sheep by omega-3 long-chain polyunsaturates.
MedLine Citation:
PMID:  10026118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A positive correlation has been shown between dietary intake of long-chain omega-3 fatty acids in late pregnancy and gestation length in pregnant women and experimental animals. To determine whether omega-3 fatty acids have an effect on preterm labor in sheep, a fish oil concentrate emulsion was continuously infused to six pregnant ewes from 124 days gestational age. At 125 days, betamethasone was administered to the fetus to produce preterm labor. Both the onset of labor and the time of delivery were delayed by the fish oil emulsion. Two of the omega-3-infused ewes reverted from contractions to nonlabor, an effect never previously observed for experimental glucocorticoid-induced preterm labor in sheep. Maternal plasma estradiol and maternal and fetal prostaglandin E2 rose in control ewes but not in those infused with omega-3 fatty acid. The ability of omega-3 fatty acids to delay premature delivery in sheep indicates their possible use as tocolytics in humans. Premature labor is the major cause of neonatal death and long-term disability, and these studies present information that may lead to a novel therapeutic regimen for the prevention of preterm delivery in human pregnancy.
Authors:
M Baguma-Nibasheka; J T Brenna; P W Nathanielsz
Related Documents :
18928978 - The frequency of microbial invasion of the amniotic cavity and histologic chorioamnioni...
20347088 - Induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone.
6911898 - Possible role of prekallikrein in the mechanism of labor.
15925438 - Fetal head position during the second stage of labor: comparison of digital vaginal exa...
12487768 - Epidemiology and prevention of thyroid disease in pregnancy.
18667748 - Progesterone and placentation increase secreted phosphoprotein one (spp1 or osteopontin...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of reproduction     Volume:  60     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-03-11     Completed Date:  1999-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  698-701     Citation Subset:  IM    
Affiliation:
Laboratory for Pregnancy and Newborn Research, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Animals
Betamethasone
Dinoprostone / blood
Estradiol / blood
Fat Emulsions, Intravenous
Fatty Acids, Omega-3 / administration & dosage,  therapeutic use*
Female
Fetal Blood / metabolism
Fish Oils / administration & dosage
Gestational Age
Hydrocortisone / blood
Obstetric Labor, Premature / chemically induced,  drug therapy*
Pregnancy
Progesterone / blood
Sheep
Grant Support
ID/Acronym/Agency:
HD 21350/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids, Omega-3; 0/Fish Oils; 363-24-6/Dinoprostone; 378-44-9/Betamethasone; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cloning, sequencing, and localization of bovine estrogen receptor-beta within the ovarian follicle.
Next Document:  An intact sperm nuclear matrix may be necessary for the mouse paternal genome to participate in embr...