| Delay eyeblink classical conditioning is impaired in Fragile X syndrome. | |
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MedLine Citation:
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PMID: 19485573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors examined 400 ms delay eyeblink classical conditioning in 20 participants with Fragile X syndrome ages 17 to 77 years, and 20 age-matched, healthy control participants. The participants in the Fragile X group demonstrated impaired learning and abnormal conditioned response timing. Adults with Fragile X (n=16) were also tested at two successive 12-month follow-up sessions to examine reacquisition and long-term retention. Participants in groups who were older and younger than 45 years demonstrated significant learning during each reacquisition session. Younger participants demonstrated greater retention of the conditioned stimulus/unconditioned stimulus association at each follow-up session than older participants. Fragile X impairs the acquisition and timing of conditioned eyeblink responses, but with repeated training adults with Fragile X syndrome show significant plasticity. |
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Authors:
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Michael J Tobia; Diana S Woodruff-Pak |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Behavioral neuroscience Volume: 123 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-02 Completed Date: 2009-08-13 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 665-76 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 APA, all rights reserved. |
Affiliation:
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Department of Psychology, Temple University, Philadelphia, PA 19122, USA. mtobia@temple.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Analysis of Variance Association Learning Blinking Conditioning, Classical* Conditioning, Eyelid* Female Follow-Up Studies Fragile X Syndrome / psychology* Humans Male Middle Aged Reaction Time Retention (Psychology) Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AG09752/AG/NIA NIH HHS; AG21025/AG/NIA NIH HHS; AG23742/AG/NIA NIH HHS; R01 AG021925-01A1/AG/NIA NIH HHS; R01 AG023742-01A2/AG/NIA NIH HHS |
| Comments/Corrections | |
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