Document Detail

Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results.
MedLine Citation:
PMID:  19610174     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To present the possible positive effect of dehydroepiandrosterone administration in assisted reproduction and especially in poor responders, women with diminished ovarian reserve, premature ovarian failure and premature ovarian aging in the course of ovarian stimulation protocols followed either by intrauterine insemination or IVF. RECENT FINDINGS: Overall, 50-75 mg of dehydroepiandrosterone supplementation for at least 4 months may either result in natural conception or considerably improves intrauterine insemination and IVF outcome and pregnancy rates to women with confirmed diminished ovarian reserve, premature ovarian failure or premature ovarian aging. Positive effect has been reported to oocyte and embryo quality, even to women aged 40-47 years. The number of euploid embryos is increased, and miscarriage rate is decreased. SUMMARY: Although more data on the dehydroepiandrosterone effect on assisted reproduction are needed, results obtained over the last few years confirm the improvement of oocyte production and pregnancy rates. No significant side effects are reported, and those include mainly hirstusism and acne.
Leonidas Mamas; Eudoxia Mamas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  21     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-16     Completed Date:  2009-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  306-8     Citation Subset:  IM    
3 Kifissias Av., Marousi 15123, Athens, Greece.
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MeSH Terms
Age Factors
Aging / physiology
Dehydroepiandrosterone / adverse effects,  pharmacology*
Fertility Agents, Female / adverse effects,  pharmacology*
Infertility, Female / drug therapy*
Ovarian Failure, Premature / drug therapy
Ovulation Induction
Pregnancy Rate*
Reproductive Techniques, Assisted*
Treatment Outcome
Reg. No./Substance:
0/Fertility Agents, Female; 53-43-0/Dehydroepiandrosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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