| Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results. | |
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MedLine Citation:
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PMID: 19610174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To present the possible positive effect of dehydroepiandrosterone administration in assisted reproduction and especially in poor responders, women with diminished ovarian reserve, premature ovarian failure and premature ovarian aging in the course of ovarian stimulation protocols followed either by intrauterine insemination or IVF. RECENT FINDINGS: Overall, 50-75 mg of dehydroepiandrosterone supplementation for at least 4 months may either result in natural conception or considerably improves intrauterine insemination and IVF outcome and pregnancy rates to women with confirmed diminished ovarian reserve, premature ovarian failure or premature ovarian aging. Positive effect has been reported to oocyte and embryo quality, even to women aged 40-47 years. The number of euploid embryos is increased, and miscarriage rate is decreased. SUMMARY: Although more data on the dehydroepiandrosterone effect on assisted reproduction are needed, results obtained over the last few years confirm the improvement of oocyte production and pregnancy rates. No significant side effects are reported, and those include mainly hirstusism and acne. |
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Authors:
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Leonidas Mamas; Eudoxia Mamas |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in obstetrics & gynecology Volume: 21 ISSN: 1473-656X ISO Abbreviation: Curr. Opin. Obstet. Gynecol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-16 Completed Date: 2009-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007264 Medline TA: Curr Opin Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 306-8 Citation Subset: IM |
Affiliation:
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3 Kifissias Av., Marousi 15123, Athens, Greece. leonidasmamas@neogenesis.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging / physiology Dehydroepiandrosterone / adverse effects, pharmacology* Female Fertility Agents, Female / adverse effects, pharmacology* Humans Infertility, Female / drug therapy* Ovarian Failure, Premature / drug therapy Ovulation Induction Pregnancy Pregnancy Rate* Reproductive Techniques, Assisted* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 53-43-0/Dehydroepiandrosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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