Document Detail


Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year.
MedLine Citation:
PMID:  10843528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study explored associations between serum dehydroepiandrosterone sulfate (DHEAS), free and total testosterone levels, and HIV illness markers, including viral load, and the behavioral problems of fatigue and depressed mood. Subjects were 169 HIV-positive men evaluated at baseline, 6, and 12 months for levels of DHEAS, total and free testosterone, HIV RNA, CD4, HIV symptoms, opportunistic illnesses, fatigue, and depression. Men with AIDS (N = 105), compared with men with less advanced illness, had lower mean levels of DHEAS. Baseline DHEAS was positively correlated with CD4 count, HIV symptom severity, and was inversely correlated with HIV RNA. Baseline DHEAS below the laboratory reference range (96 microg/dl) was associated with history of opportunistic infections and malignancies (adjusted odds ratio [OR], 4.4; 95% confidence interval [CI], 1.9-10.4) and with incidence of these complications or death over 1 year (adjusted OR, 2.6; 95% CI, 1-7.2). Initiating protease inhibitor combination therapy was associated with an increase in DHEAS over 6 months. Free testosterone was inversely correlated with HIV RNA, but there were no other significant associations between testosterone and HIV illness markers. No hormone was related to fatigue or depression. This study confirms that low serum DHEAS is associated with HIV illness markers, including viral load, and carries negative prognostic value. Further, protease inhibitor therapy may result in increased circulating DHEAS.
Authors:
S J Ferrando; J G Rabkin; L Poretsky
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  22     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-06-20     Completed Date:  2000-06-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  146-54     Citation Subset:  IM; X    
Affiliation:
Department of Psychiatry, Cornell University Medical College, New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Sectional Studies
Dehydroepiandrosterone Sulfate / blood*
Depressive Disorder / complications
Disease Progression
Drug Therapy, Combination
Fatigue / complications
HIV Infections / blood*,  complications,  drug therapy
Humans
Male
Reverse Transcriptase Inhibitors / therapeutic use
Severity of Illness Index
Testosterone / blood*
Viral Load
Grant Support
ID/Acronym/Agency:
MH42277-11/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Reverse Transcriptase Inhibitors; 58-22-0/Testosterone; 651-48-9/Dehydroepiandrosterone Sulfate

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