| Dehydroepiandrosterone pretreatment protects rats against the pro-oxidant and necrogenic effects of carbon tetrachloride. | |
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MedLine Citation:
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PMID: 8250954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single intraperitoneal injection of dehydroepiandrosterone (3 beta-hydroxy-5-androsten-17-one, DHEA) 17 hr before carbon tetrachloride (CCl4) poisoning protects rats against liver injury induced by the haloalkane. In liver homogenates, both the increase in malondialdehyde production and the formation of fluorescent lipid peroxidation products are significantly reduced. Also, liver microsomes obtained from DHEA-pretreated rats incubated in vitro with CCl4 are less susceptible to lipid peroxidation than microsomes from normal animals. The release of liver enzymes into the blood is much reduced in DHEA-pretreated rats, confirming a cause-effect relationship between lipid peroxidation and hepatocyte death. Treatment with DHEA inhibits neither glucose-6-phosphate dehydrogenase activity in the cytosol, nor the microsomal mixed function oxidase system (cytochrome P450 content, aminopyrine demethylase and ethoxycoumarin de-ethylase activities). In animals treated with DHEA, the liver content of total glutathione and vitamin E is not modified. These results support the hypothesis that DHEA protects against CCl4-induced liver injury through its own antioxidant activity, rather than by interfering with the metabolism of the toxin or with the tissue level of primary antioxidants. |
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Authors:
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M Aragno; E Tamagno; G Boccuzzi; E Brignardello; E Chiarpotto; A Pizzini; O Danni |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical pharmacology Volume: 46 ISSN: 0006-2952 ISO Abbreviation: Biochem. Pharmacol. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-01-04 Completed Date: 1994-01-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0101032 Medline TA: Biochem Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1689-94 Citation Subset: IM |
Affiliation:
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General Pathology Institute, Sassari, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Carbon Tetrachloride / antagonists & inhibitors* Carbon Tetrachloride Poisoning / enzymology, prevention & control* Dehydroepiandrosterone / pharmacology* Lipid Peroxidation / drug effects Malondialdehyde / analysis Microsomes, Liver / drug effects, enzymology Rats |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 53-43-0/Dehydroepiandrosterone; 542-78-9/Malondialdehyde; 56-23-5/Carbon Tetrachloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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