| Dehydroepiandrosterone inhibits CD40/CD40L expression on human umbilical vein endothelial cells induced by interferon gamma. | |
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MedLine Citation:
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PMID: 19015047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many studies indicated that the CD40/CD40 ligand (CD40L) pathway plays an important role in the pathogenesis of atherosclerosis. It has been demonstrated a protective role of dehydroepiandrosterone (DHEA) against atherosclerosis. The major purpose of our present work was to assess whether DHEA could decrease the expression of CD40 and CD40L on human umbilical vein endothelial cells (HUVECs) induced by interferon gamma (IFN-gamma). We found that DHEA inhibited IFN-gamma-induced expression of CD40 and CD40L in a dose-dependent manner. Moreover, DHEA inhibited IFN-gamma-induced activation of extracellular signal regulated kinase (ERK1/2). The important role of ERK1/2 in DHEA effect was further confirmed by using ERK1/2 inhibitor U0126. These findings suggest that DHEA can inhibit the expression of molecules involved in the inflammatory process in endothelial cells activated with IFN-gamma. Such antagonism is at least partially mediated through the modulation of ERK1/2 pathway. Therefore, DHEA may be considered as a potential preventive intervention for atherosclerosis. |
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Authors:
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Yan Li; Zunen Xia; Ming Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-17 |
Journal Detail:
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Title: International immunopharmacology Volume: 9 ISSN: 1878-1705 ISO Abbreviation: Int. Immunopharmacol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-26 Completed Date: 2009-04-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 168-72 Citation Subset: IM |
Affiliation:
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Department of Clinical Laboratory, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, China. yanlitf@yahoo.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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pharmacology* Antigens, CD40 / antagonists & inhibitors*, biosynthesis Atherosclerosis / immunology*, prevention & control Butadienes / pharmacology CD40 Ligand / antagonists & inhibitors*, biosynthesis Cells, Cultured Dehydroepiandrosterone / pharmacology* Endothelium, Vascular / drug effects*, immunology Enzyme Inhibitors / pharmacology Extracellular Signal-Regulated MAP Kinases / antagonists & inhibitors, metabolism Humans Interferon-gamma / pharmacology Nitriles / pharmacology Signal Transduction Umbilical Veins / cytology |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Antigens, CD40; 0/Butadienes; 0/Enzyme Inhibitors; 0/Nitriles; 0/U 0126; 147205-72-9/CD40 Ligand; 53-43-0/Dehydroepiandrosterone; 82115-62-6/Interferon-gamma; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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