| Dehydroepiandrosterone induces apoptosis of thymocyte through Fas/Fas-L pathway. | |
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MedLine Citation:
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PMID: 15351316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dehydroepiandrosterone (DHEA), the most plentiful steroid hormone, has been convincingly known to have many biological effects and diverse influence in various types of cells, tissues and organs. The effects of DHEA on the humoral and cellular immune response are widely tested, but it is unclear whether DHEA itself serves as an activator of immune function and the literature pertaining to the in vitro effects of DHEA remains contested. In the present paper, the effects of DHEA on the thymocytes in vitro were studied. The results showed that DHEA could enhance the expression of Fas and Fas-L and induce thymocyte apoptosis. This suggests that dehydroepiandrosterone may induce the apoptosis of thymocyte through Fas/Fas-L pathway. |
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Authors:
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Jun Liang; Genhong Yao; Linsong Yang; Yayi Hou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International immunopharmacology Volume: 4 ISSN: 1567-5769 ISO Abbreviation: Int. Immunopharmacol. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-09-07 Completed Date: 2005-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1467-75 Citation Subset: IM |
Affiliation:
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Immunology and Reproductive Biology Lab, Medical School, Nanjing University, Nanjing 210093, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD95 / biosynthesis*, immunology Apoptosis / drug effects*, immunology Cell Survival / drug effects, immunology Cells, Cultured Dehydroepiandrosterone / pharmacology* Fas Ligand Protein Flow Cytometry Membrane Glycoproteins / biosynthesis*, immunology Mice RNA, Messenger / biosynthesis Reverse Transcriptase Polymerase Chain Reaction Thymus Gland / cytology, drug effects*, immunology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Fas Ligand Protein; 0/Fasl protein, mouse; 0/Membrane Glycoproteins; 0/RNA, Messenger; 53-43-0/Dehydroepiandrosterone |
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