Document Detail


Dehydroepiandrosterone induces apoptosis of thymocyte through Fas/Fas-L pathway.
MedLine Citation:
PMID:  15351316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dehydroepiandrosterone (DHEA), the most plentiful steroid hormone, has been convincingly known to have many biological effects and diverse influence in various types of cells, tissues and organs. The effects of DHEA on the humoral and cellular immune response are widely tested, but it is unclear whether DHEA itself serves as an activator of immune function and the literature pertaining to the in vitro effects of DHEA remains contested. In the present paper, the effects of DHEA on the thymocytes in vitro were studied. The results showed that DHEA could enhance the expression of Fas and Fas-L and induce thymocyte apoptosis. This suggests that dehydroepiandrosterone may induce the apoptosis of thymocyte through Fas/Fas-L pathway.
Authors:
Jun Liang; Genhong Yao; Linsong Yang; Yayi Hou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International immunopharmacology     Volume:  4     ISSN:  1567-5769     ISO Abbreviation:  Int. Immunopharmacol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2005-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100965259     Medline TA:  Int Immunopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1467-75     Citation Subset:  IM    
Affiliation:
Immunology and Reproductive Biology Lab, Medical School, Nanjing University, Nanjing 210093, PR China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD95 / biosynthesis*,  immunology
Apoptosis / drug effects*,  immunology
Cell Survival / drug effects,  immunology
Cells, Cultured
Dehydroepiandrosterone / pharmacology*
Fas Ligand Protein
Flow Cytometry
Membrane Glycoproteins / biosynthesis*,  immunology
Mice
RNA, Messenger / biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Thymus Gland / cytology,  drug effects*,  immunology,  metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD95; 0/Fas Ligand Protein; 0/Fasl protein, mouse; 0/Membrane Glycoproteins; 0/RNA, Messenger; 53-43-0/Dehydroepiandrosterone

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