Document Detail

Dehydroepiandrosterone in the nucleus accumbens is associated with early onset of depressive-behavior: a study in an animal model of childhood depression.
MedLine Citation:
PMID:  17919828     Owner:  NLM     Status:  MEDLINE    
Although the monoamine theory of depression is well studied, regarding childhood depression it is poorly supported. Antidepressant treatments affecting the monoaminergic system fail to ameliorate childhood depression in the same manner that they affect adult depression. The present study used the Flinders sensitive line (FSL) rat, a well-investigated genetic animal model of depression and Sprague-Dawley (SD) rats as controls. We co-measured monoamines and dehydroepiandrosterone (DHEA) levels in the nucleus accumbens on postnatal day 1, in prepubertal rats (35 days), and adult rats (4 months) in order to examine developmental characteristics in the monoamine systems. The results suggest that there are different ontogenetic patterns of monoaminergic activity in FSL and SD rats. While monoamine levels were different only in adulthood, FSL rats exhibited lower DHEA levels already in prepubertal childhood. These differences may be relevant to the poor response to antidepressant drugs observed in depressed children and suggest DHEA as a new marker for childhood depression.
O Malkesman; M Shayit; R Genud; A Zangen; N Kinor; R Maayan; A Weizman; A Weller; G Yadid
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-24
Journal Detail:
Title:  Neuroscience     Volume:  149     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-30     Completed Date:  2008-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  573-81     Citation Subset:  IM    
Interdisciplinary Program in the Brain Sciences, Bar-Ilan University, Israel.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Age of Onset
Biogenic Monoamines / metabolism
Dehydroepiandrosterone / metabolism*
Depressive Disorder / metabolism*
Disease Models, Animal
Dopamine / metabolism
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Nucleus Accumbens / metabolism*
Rats, Inbred Strains
Serotonin / metabolism
Sexual Maturation
Reg. No./Substance:
0/Biogenic Monoamines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 53-43-0/Dehydroepiandrosterone; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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