Document Detail


Dehydroepiandrosterone (DHEA) blocks the increase in food intake caused by neuropeptide Y (NPY) in the Zucker rat.
MedLine Citation:
PMID:  17263089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have demonstrated that neuropeptide Y (NPY) reduced the neural production of dehydroepiandrosterone (DHEA) in frog hypothalamic explants. The objective of this study was to assess if DHEA can block the NPY induced increase in food intake in lean and obese Zucker rats. Rats were given one of the following four treatments: sterile water/dimethylsulfoxide (DMSO), NPY/DMSO, water/DHEA, and NPY/DHEA. Immediately after administration of their respective treatment, rats were exposed to macronutrients for 4 h and food intake was monitored. NPY caused a significant increase in total calories consumed compared to control. Co-administration of DHEA along with NPY blocked this NPY dependent effect. These results suggest that DHEA blocks the over-eating in satiated rats induced by NPY. Measurement of changes in regional hypothalamic and raphe monoamine neurotransmitters known to affect food intake suggested a possible role of serotonin fluctuations in the ventromedial hypothalamus (VMH) guiding this behaviour.
Authors:
Daniel Navar; Dana Saulis; Connie Corll; Frank Svec; Johnny R Porter
Related Documents :
19732749 - Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropepti...
16278259 - Elevated peptide yy levels in adolescent girls with anorexia nervosa.
18155809 - Effects of selective modulation of the central melanocortin-3-receptor on food intake a...
19445969 - Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghre...
12069929 - Principles for interpreting interactions among the multiple systems that influence food...
19362579 - Targeting the ghrelin receptor to regulate food intake.
23366939 - 3d localization of circular feature in 2d image and application to food volume estimation.
12175589 - Dissociation of the effects of preload volume and energy content on subjective appetite...
9048529 - Food allergy in human immunodeficiency virus (hiv) infection.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  9     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:    2006 Oct-Dec
Date Detail:
Created Date:  2007-01-31     Completed Date:  2007-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
Affiliation:
Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animals
Dehydroepiandrosterone / pharmacology*
Dose-Response Relationship, Drug
Energy Intake / drug effects*
Female
Neuropeptide Y / physiology*
Obesity / genetics,  physiopathology
Rats
Rats, Zucker
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 53-43-0/Dehydroepiandrosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neurophysiological characterization of a functionally active drink containing extracts of ginkgo and...
Next Document:  Early undernutrition decreases the number of neurons in the locus coeruleus of rats.