Document Detail

Dehydroepiandrosterone (DHEA) blocks the increase in food intake caused by neuropeptide Y (NPY) in the Zucker rat.
MedLine Citation:
PMID:  17263089     Owner:  NLM     Status:  MEDLINE    
Recent studies have demonstrated that neuropeptide Y (NPY) reduced the neural production of dehydroepiandrosterone (DHEA) in frog hypothalamic explants. The objective of this study was to assess if DHEA can block the NPY induced increase in food intake in lean and obese Zucker rats. Rats were given one of the following four treatments: sterile water/dimethylsulfoxide (DMSO), NPY/DMSO, water/DHEA, and NPY/DHEA. Immediately after administration of their respective treatment, rats were exposed to macronutrients for 4 h and food intake was monitored. NPY caused a significant increase in total calories consumed compared to control. Co-administration of DHEA along with NPY blocked this NPY dependent effect. These results suggest that DHEA blocks the over-eating in satiated rats induced by NPY. Measurement of changes in regional hypothalamic and raphe monoamine neurotransmitters known to affect food intake suggested a possible role of serotonin fluctuations in the ventromedial hypothalamus (VMH) guiding this behaviour.
Daniel Navar; Dana Saulis; Connie Corll; Frank Svec; Johnny R Porter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  9     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:    2006 Oct-Dec
Date Detail:
Created Date:  2007-01-31     Completed Date:  2007-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
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MeSH Terms
Animal Feed
Dehydroepiandrosterone / pharmacology*
Dose-Response Relationship, Drug
Energy Intake / drug effects*
Neuropeptide Y / physiology*
Obesity / genetics,  physiopathology
Rats, Zucker
Reg. No./Substance:
0/Neuropeptide Y; 53-43-0/Dehydroepiandrosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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