Document Detail

Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the rat.
MedLine Citation:
PMID:  18585427     Owner:  NLM     Status:  MEDLINE    
Thermolysis of proteins produces xenobiotic amino-acids such as the potentially toxic lysinoalanine, and the alkylating agent, dehydroalanine, which have been considered possible health hazards. We observed that thermolyzed casein promoted aberrant crypt foci (ACF) and colon cancer growth in rats initiated with azoxymethane and speculated that promotion might be due to the formation of these compounds. To test this notion we first measured the concentration of the modified amino acids as a function of thermolysis time. The concentration of dehydroalanine in the casein paralleled the degree of promotion, that of lysinoalanine did not. We then tested diets containing foods with high levels of dehydroalanine (thermolyzed sodium-caseinate, cooked Swiss cheese) for their effect on ACF promotion. They decreased the number and/or size of ACF significantly, indicating that dehydroalanine did not promote, but protected rats against colon carcinogenesis. These results do not support the notion that lysinoalanine or dehydroalanine are a hazard with respect to colon carcinogenicity.
Denis E Corpet; Sylviane Taché; Michael C Archer; W Robert Bruce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-10
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-11-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3037-42     Citation Subset:  IM    
Université de Toulouse, INRA, ENVT, UMR1089 Xénobiotiques, F-31076 Toulouse, France.
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MeSH Terms
Alanine / analogs & derivatives*,  analysis,  metabolism,  toxicity
Azoxymethane / toxicity
Carcinogenicity Tests
Caseins / chemistry*,  toxicity
Cheese / analysis
Colonic Neoplasms / chemically induced*,  pathology
Feces / chemistry
Hot Temperature
Intestinal Mucosa / pathology
Lysinoalanine / analysis,  metabolism,  toxicity*
Rats, Inbred F344
Reg. No./Substance:
0/Caseins; 18810-04-3/Lysinoalanine; 1948-56-7/dehydroalanine; 25843-45-2/Azoxymethane; 56-41-7/Alanine

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