| Dehydration enhances endotoxin fever by increased production of endogenous pyrogen. | |
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MedLine Citation:
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PMID: 3460355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The febrile responses in rats to an intravenous injection of the bacterial endotoxin Salmonella typhosa were investigated under normally hydrated and dehydrated conditions. When endotoxin was injected intravenously into the dehydrated rats, a biphasic-patterned fever resulted, whereas in normal rats an intravenous injection of endotoxin did not induce fever. No significant differences in febrile responses to the intravenous endogenous pyrogen (EP), prostaglandin E2, and intracerebroventricular prostaglandin E2 between normal and dehydrated rats were observed. When the blood plasma obtained from rats with endotoxin-induced fever under dehydrated conditions was transferred to the normal rats, a significant rise in the body temperature was induced. The effect of hydration by an administration of the hypotonic solution after dehydration was examined in endotoxin-induced fever and in changes of the basic blood parameters. It is concluded that febrile responses to endotoxin during dehydrated condition are caused by an increased production of EP. The migration of leukocytes from circulation to any other tissue will be an important factor in producing EP under dehydrated conditions. Furthermore, under dehydrated condition, EP may be produced by numerous macrophages in tissues in vivo, where many kinds of leukocytes migrate and exchange signals with each other in developing an immune response. |
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Authors:
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A Morimoto; N Murakami; T Ono; T Watanabe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 251 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-08-21 Completed Date: 1986-08-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R41-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Dehydration / complications* Dinoprostone Endotoxins* Fever / chemically induced, complications* Injections, Intravenous Injections, Intraventricular Interleukin-1* Leukocyte Count Male Potassium / blood Prostaglandins E / administration & dosage, pharmacology Protein Biosynthesis* Rabbits Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Interleukin-1; 0/Prostaglandins E; 0/leukocyte endogenous mediator; 363-24-6/Dinoprostone; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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