Document Detail


Dehydration-anorexia derives from a reduction in meal size, but not meal number.
MedLine Citation:
PMID:  21854794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anorexia that results from extended periods of cellular dehydration is an important physiological adaptation that limits the intake of osmolytes from food and helps maintain the integrity of fluid compartments. The ability to experimentally control both the development and reversal of anorexia, together with the understanding of underlying hormonal and neuropeptidergic signals, makes dehydration (DE)-anorexia a powerful model for exploring the interactions of neural networks that stimulate and inhibit food intake. However, it is not known which meal parameters are affected by cellular dehydration to generate anorexia. Here we use continuous and high temporal resolution recording of food and fluid intake, together with a drinking-explicit method of meal pattern analysis to explore which meal parameters are modified during DE-anorexia. We find that the most important factor responsible for DE-anorexia is the failure to maintain feeding behavior once a meal has started, rather than the ability to initiate a meal, which remains virtually intact. This outcome is consistent with increased sensitivity to satiation signals and post-prandial satiety mechanisms. We also find that DE-anorexia significantly disrupts the temporal distribution of meals across the day so that the number of nocturnal meals gradually decreases while diurnal meal number increases. Surprisingly, once DE-anorexia is reversed this temporal redistribution is maintained for at least 4 days after normal food intake has resumed, which may allow increased daily food intake even after normal satiety mechanisms are reinstated. Therefore, DE-anorexia apparently develops from a selective targeting of those neural networks that control meal termination, whereas meal initiation mechanisms remain viable.
Authors:
Christina N Boyle; Sarah M Lorenzen; Douglas Compton; Alan G Watts
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-11
Journal Detail:
Title:  Physiology & behavior     Volume:  105     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-03-26     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  305-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
The Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089-2520, United States. boyle@vetphys.uzh.ch
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anorexia / physiopathology*
Dehydration / physiopathology*
Drinking / physiology
Drinking Behavior / physiology
Eating / physiology*
Feeding Behavior / physiology*
Male
Rats
Rats, Sprague-Dawley
Time Factors
Grant Support
ID/Acronym/Agency:
MH-066168/MH/NIMH NIH HHS; R01 MH066168-10/MH/NIMH NIH HHS
Comments/Corrections

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