Document Detail


Dehydration affects brain structure and function in healthy adolescents.
MedLine Citation:
PMID:  20336685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It was recently observed that dehydration causes shrinkage of brain tissue and an associated increase in ventricular volume. Negative effects of dehydration on cognitive performance have been shown in some but not all studies, and it has also been reported that an increased perceived effort may be required following dehydration. However, the effects of dehydration on brain function are unknown. We investigated this question using functional magnetic resonance imaging (fMRI) in 10 healthy adolescents (mean age = 16.8, five females). Each subject completed a thermal exercise protocol and nonthermal exercise control condition in a cross-over repeated measures design. Subjects lost more weight via perspiration in the thermal exercise versus the control condition (P < 0.0001), and lateral ventricle enlargement correlated with the reduction in body mass (r = 0.77, P = 0.01). Dehydration following the thermal exercise protocol led to a significantly stronger increase in fronto-parietal blood-oxygen-level-dependent (BOLD) response during an executive function task (Tower of London) than the control condition, whereas cerebral perfusion during rest was not affected. The increase in BOLD response after dehydration was not paralleled by a change in cognitive performance, suggesting an inefficient use of brain metabolic activity following dehydration. This pattern indicates that participants exerted a higher level of neuronal activity in order to achieve the same performance level. Given the limited availability of brain metabolic resources, these findings suggest that prolonged states of reduced water intake may adversely impact executive functions such as planning and visuo-spatial processing.
Authors:
Matthew J Kempton; Ulrich Ettinger; Russell Foster; Steven C R Williams; Gemma A Calvert; Adam Hampshire; Fernando O Zelaya; Ruth L O'Gorman; Terry McMorris; Adrian M Owen; Marcus S Smith
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human brain mapping     Volume:  32     ISSN:  1097-0193     ISO Abbreviation:  Hum Brain Mapp     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-03-25     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-9     Citation Subset:  IM    
Copyright Information:
Hum Brain Mapp, 2010. © 2010 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Analysis of Variance
Body Temperature
Brain / pathology*,  physiopathology*
Brain Mapping
Cognition / physiology
Cross-Over Studies
Dehydration / pathology*,  physiopathology*
Executive Function / physiology
Exercise / physiology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Reaction Time / physiology
Grant Support
ID/Acronym/Agency:
MC_U105559847//Medical Research Council; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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