Document Detail

Degree and duration of reversal by naloxone of effects of morphine in conscious subjects.
MedLine Citation:
PMID:  4833964     Owner:  NLM     Status:  MEDLINE    
The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.
J M Evans; M I Hogg; J N Lunn; M Rosen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  2     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1974 Jun 
Date Detail:
Created Date:  1974-08-23     Completed Date:  1974-08-23     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  589-91     Citation Subset:  AIM; IM    
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MeSH Terms
Arousal / drug effects
Blood Pressure / drug effects
Carbon Dioxide
Morphine / antagonists & inhibitors*
Naloxone / pharmacology*
Pupil / drug effects
Respiration / drug effects
Reg. No./Substance:
124-38-9/Carbon Dioxide; 465-65-6/Naloxone; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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