Document Detail

Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation.
MedLine Citation:
PMID:  12494677     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: HLA-A/-B matching on a split typing level is more laborious, more expensive and offers less chances for a well-fitting match than does matching on the conventional broad typing level. It is important, therefore, to investigate whether or not split matching offers advantages and would, therefore, be advisable. METHODS: 303 high-risk patients out of 2,471 keratoplasty patients from 1982 through 1996, whose histories were all followed prospectively, could be re-evaluated retrospectively according to their broad or split matching levels ('good' vs. 'moderate'). RESULTS: Only a 'good' split level matching was significantly better than a 'moderate' one in the long run (up to 12 years). For the broad level matching this was only true for the first few years after keratoplasty. CONCLUSION: If only HLA-A/-B are matched and if only results longer than 3-4 years (up to 12 years) are taken into consideration, then split level matching offers clear-cut advantages over broad level matching.
W Houdijn Beekhuis; Marjolijn Bartels; Ilias I N Doxiadis; Gabriel van Rij
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developments in ophthalmology     Volume:  36     ISSN:  0250-3751     ISO Abbreviation:  Dev Ophthalmol     Publication Date:  2003  
Date Detail:
Created Date:  2002-12-23     Completed Date:  2003-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8010321     Medline TA:  Dev Ophthalmol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  12-21     Citation Subset:  IM    
Eye Hospital, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Cornea / immunology*
Graft Survival / physiology*
HLA-A Antigens / immunology*
HLA-B Antigens / immunology*
Histocompatibility / physiology*
Histocompatibility Testing
Keratoplasty, Penetrating / immunology*
Middle Aged
Retrospective Studies
Tissue Donors
Reg. No./Substance:
0/HLA-A Antigens; 0/HLA-B Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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