| Degree of compatibility for HLA-A and -B affects outcome in high-risk corneal transplantation. | |
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MedLine Citation:
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PMID: 12494677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: HLA-A/-B matching on a split typing level is more laborious, more expensive and offers less chances for a well-fitting match than does matching on the conventional broad typing level. It is important, therefore, to investigate whether or not split matching offers advantages and would, therefore, be advisable. METHODS: 303 high-risk patients out of 2,471 keratoplasty patients from 1982 through 1996, whose histories were all followed prospectively, could be re-evaluated retrospectively according to their broad or split matching levels ('good' vs. 'moderate'). RESULTS: Only a 'good' split level matching was significantly better than a 'moderate' one in the long run (up to 12 years). For the broad level matching this was only true for the first few years after keratoplasty. CONCLUSION: If only HLA-A/-B are matched and if only results longer than 3-4 years (up to 12 years) are taken into consideration, then split level matching offers clear-cut advantages over broad level matching. |
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Authors:
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W Houdijn Beekhuis; Marjolijn Bartels; Ilias I N Doxiadis; Gabriel van Rij |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Developments in ophthalmology Volume: 36 ISSN: 0250-3751 ISO Abbreviation: Dev Ophthalmol Publication Date: 2003 |
Date Detail:
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Created Date: 2002-12-23 Completed Date: 2003-01-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8010321 Medline TA: Dev Ophthalmol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 12-21 Citation Subset: IM |
Affiliation:
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Eye Hospital, Erasmus Medical Center, Rotterdam, The Netherlands. hi.beekhuis@planet.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Cornea / immunology* Female Graft Survival / physiology* HLA-A Antigens / immunology* HLA-B Antigens / immunology* Histocompatibility / physiology* Histocompatibility Testing Humans Keratoplasty, Penetrating / immunology* Male Middle Aged Retrospective Studies Tissue Donors |
| Chemical | |
Reg. No./Substance:
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0/HLA-A Antigens; 0/HLA-B Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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