Document Detail


Degree of Polymerization of Inulin-type Fructans Differentially Affects Number of Lactic Acid-Bacteria, Intestinal Immune Functions and Immunoglobulin A Secretion in the Rat Cecum.
MedLine Citation:
PMID:  21506616     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We examined the role of degree of polymerization (DP) of inulin-fructans in modulating the interaction between lactic acid bacteria and IgA cecal secretion. Rats were fed a control diet or a diet containing one of the fructans with different DP. Consuming fructans increased the cecal IgA concentrations in the order of DP4 > DP8 > DP16. Cecal lactobacilli counts were higher in DP4, DP8 and DP16, while bifidobacteria were higher in DP8, DP16 and DP23. Cecal IgA concentrations were correlated with cecal lactobacilli counts (P < 0.01). DP4, DP8 and DP16, but not DP23 significantly increased IgA-producing plasma cells in the cecal mucosa. IFN-γ and IL-10 production in the cecal CD4+ T cells was enhanced solely in DP4. The results show that fructans with lower DP enhance cecal IgA secretion and increase the plasma cells, and suggest that the increased lactobacilli may contribute to the stimulation of cecal IgA secretion.
Authors:
Hiroyuki Ito; Naoki Takemura; Kei Sonoyama; Hirokazu Kawagishi; David Topping; Michael A Conlon; Tatsuya Morita
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-21
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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