Document Detail

Degradation of uric acid by certain aerobic bacteria.
MedLine Citation:
PMID:  4979099     Owner:  NLM     Status:  MEDLINE    
We have isolated and identified nine cultures of aerobic bacteria capable of growing on an elective medium containing uric acid as the only source of carbon, nitrogen, and energy. Four of these cultures were identified as Aerobacter aerogenes, two as Klebsiella pneumoniae, and the remainder as Serratia killiensis, Pseudomonas aeruginosa, and Bacillus species. Another culture identified as P. fluorescens required both glucose and uric acid for growth. When 23 laboratory stock cultures were inoculated into the uric acid medium, A. aerogenes, B. subtilis, Mycobacterium phlei, P. aeruginosa, and S. marcescens were able to grow. These five cultures also grew when the uric acid was replaced with adenine, guanine, hypoxanthine, xanthine, or allantoin, but growth was poor. In all of these media, including the uric acid medium, addition of glucose along with the nitrogenous compounds yielded good growth. Induction experiments demonstrated that the ability of A. aerogenes, K. pneumoniae, P. aeruginosa, P. fluorescens, S. kiliensis, S. marcescens, B. subtilis, and Bacillus sp. to degrade uric acid is an induced property. Of these organisms, only Bacillus sp. accumulated a small amount of intracellular uric acid.
M A Rouf; R F Lomprey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bacteriology     Volume:  96     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1968 Sep 
Date Detail:
Created Date:  1969-09-19     Completed Date:  1969-09-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-22     Citation Subset:  IM    
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MeSH Terms
Bacillus / metabolism*
Bacillus subtilis / metabolism
Culture Media
Enterobacter / metabolism*
Enzyme Induction
Glucose / metabolism
Klebsiella / metabolism*
Mycobacterium / metabolism
Pseudomonas / metabolism
Pseudomonas aeruginosa / metabolism*
Serratia / metabolism*
Serratia marcescens / metabolism
Uric Acid / metabolism*
Reg. No./Substance:
0/Culture Media; 50-99-7/Glucose; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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