| Degradation of thyrotropin releasing hormone and a related compound by rat liver and kidney homogenate. | |
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MedLine Citation:
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PMID: 828243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inactivation of the hypothalamic hormone by rat liver and kidney homogenates was studied, using specific radioimmunoassays for the measurement of thyrotropin releasing hormone, pGlu-His-Pro-NH2 (TRH), and for an analogous peptide, pGlu-His-Pro-OH(TRH-OH), which has been proposed as a major metabolite of TRH [NAIR et al., 1971]. The inactivation of TRH and the free acid was found to be rapid. Heat lability and saturation kinetics suggest the involvement of enzymatic processes. In liver homogenate, TRH-OH production from TRH was observed. The accumulation of TRH-OH was substantial in experiments employing near-saturation concentrations of TRH. The liver and kidney are ascribed as major sites for breakdown of TRH in vivo. |
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Authors:
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T J Visser; W Klootwijk; R Docter; G Hennemann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroendocrinology Volume: 21 ISSN: 0028-3835 ISO Abbreviation: Neuroendocrinology Publication Date: 1976 |
Date Detail:
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Created Date: 1977-04-25 Completed Date: 1977-04-25 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0035665 Medline TA: Neuroendocrinology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 204-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cross Reactions Kidney / metabolism* Liver / metabolism* Radioimmunoassay Rats Thyrotropin-Releasing Hormone / metabolism* |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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