Document Detail

Degradation products of sevoflurane during low-flow anaesthesia.
MedLine Citation:
PMID:  7880707     Owner:  NLM     Status:  MEDLINE    
Low-flow (1 litre min-1) sevoflurane anaesthesia was used in 16 patients undergoing laparoscopic cholecystectomy (group LSC, n = 8) or tympanoplasty (group TP, n = 8), and concentrations of sevoflurane degradation products were measured. Degradation products in the circuit were measured hourly, and end-tidal carbon dioxide concentration, inspired and end-tidal sevoflurane concentrations, and carbon dioxide elimination were monitored. The only degradation product detected was CF2=C(CF3)-O-CH2F (compound A). The mean maximum concentrations of compound A were 21.6 (SEM 1.6) ppm and 19.6 (0.8) ppm in the LSC and TP groups, respectively (ns). The maximum temperatures of soda lime were 46.4 (0.5) degrees C and 44.8 (0.5) degrees C, respectively (P < 0.05). Hourly end-tidal sevoflurane concentrations and concentrations of sevoflurane degradation products were the same for both groups. Carbon dioxide elimination was the same for both groups 1 h after the start of anaesthesia, but was higher in group LSC after 2 h (P < 0.05). Intraperitoneal carbon dioxide insufflation associated with laparoscopic cholecystectomy had no effect on the concentration of sevoflurane degradation products.
H Bito; K Ikeda
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  74     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-04-11     Completed Date:  1995-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  56-9     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan.
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MeSH Terms
Anesthetics / metabolism*
Carbon Dioxide / metabolism
Cholecystectomy, Laparoscopic
Ethers / metabolism*
Methyl Ethers*
Middle Aged
Reg. No./Substance:
0/Anesthetics; 0/Ethers; 0/Methyl Ethers; 124-38-9/Carbon Dioxide; 28523-86-6/sevoflurane

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