| Degradation products of sevoflurane during low-flow anaesthesia. | |
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MedLine Citation:
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PMID: 7880707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low-flow (1 litre min-1) sevoflurane anaesthesia was used in 16 patients undergoing laparoscopic cholecystectomy (group LSC, n = 8) or tympanoplasty (group TP, n = 8), and concentrations of sevoflurane degradation products were measured. Degradation products in the circuit were measured hourly, and end-tidal carbon dioxide concentration, inspired and end-tidal sevoflurane concentrations, and carbon dioxide elimination were monitored. The only degradation product detected was CF2=C(CF3)-O-CH2F (compound A). The mean maximum concentrations of compound A were 21.6 (SEM 1.6) ppm and 19.6 (0.8) ppm in the LSC and TP groups, respectively (ns). The maximum temperatures of soda lime were 46.4 (0.5) degrees C and 44.8 (0.5) degrees C, respectively (P < 0.05). Hourly end-tidal sevoflurane concentrations and concentrations of sevoflurane degradation products were the same for both groups. Carbon dioxide elimination was the same for both groups 1 h after the start of anaesthesia, but was higher in group LSC after 2 h (P < 0.05). Intraperitoneal carbon dioxide insufflation associated with laparoscopic cholecystectomy had no effect on the concentration of sevoflurane degradation products. |
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Authors:
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H Bito; K Ikeda |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 74 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-04-11 Completed Date: 1995-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 56-9 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anesthetics / metabolism* Carbon Dioxide / metabolism Cholecystectomy, Laparoscopic Ethers / metabolism* Humans Methyl Ethers* Middle Aged Tympanoplasty |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Ethers; 0/Methyl Ethers; 124-38-9/Carbon Dioxide; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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