| Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition. | |
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MedLine Citation:
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PMID: 8562787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The in vitro degradation behaviour of a wide range of poly(D,L-lactic-co-glycolic acid) (PLGA) has been examined in terms of degree of degradation and morphological change during an incubation period of up to 53 d. Gel permeation chromatography and differential scanning calorimetry were employed to characterize their degradation profiles. It was found that amorphous PLGA exhibited a transient multiple crystallization behaviour of D- or L-lactic acid oligomers during degradation. This indicated that the hydrolytic scission of ester bonds tends to primarily target the linkage between glycolic acid and D- or L-lactic acid or glycolic acid. In addition, two distinctive glass transition temperatures appeared when these crystallization phenomena occurred, suggesting the transient presence of fast and slowly eroding polymer domains within microspheres during the degradation. This study supports the heterogeneous bulk degradation for PLGA microspheres which has been proposed recently for a large specimen. |
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Authors:
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T G Park |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomaterials Volume: 16 ISSN: 0142-9612 ISO Abbreviation: Biomaterials Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-03-07 Completed Date: 1996-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1123-30 Citation Subset: IM |
Affiliation:
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School of Pharmacy, Temple University, Philadelphia, PA 19140, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials
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metabolism* Biodegradation, Environmental Calorimetry, Differential Scanning Chromatography, Gel Glycolates / metabolism Hydrolysis Lactates / metabolism Lactic Acid Microscopy, Electron, Scanning Microspheres Molecular Weight Polyglycolic Acid* Polymers / metabolism* Stereoisomerism Temperature |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Glycolates; 0/Lactates; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 79-14-1/glycolic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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