| Degradation of hydroxypropylcellulose by Rhizomucor: effects on release from theophylline-hydroxypropylcellulose tablets. | |
| | |
MedLine Citation:
|
PMID: 10089297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The stability of several varieties of hydroxypropylcellulose was monitored during 3 years of storage (1) under the conditions recommended by manufacturers and official pharmacopoeias (simple storage in closed containers) and (2) at zero relative humidity. After 1 year, severe degradation of the varieties with lower initial pH and particle size stored at ambient relative humidity was shown by changes in their molecular weight and in the pH and apparent viscosity of 2% aqueous dispersions. Microbiological analyses showed the observed degradation to be attributable to the action of fungi of the genus Rhizomucor. The changes in apparent viscosity significantly affected the release of theophylline from direct compression tablets formulated with the degraded excipients. |
| | |
Authors:
|
C Alvarez-Lorenzo; R Duro; J L Gómez-Amoza; R Martínez-Pacheco; C Souto; A Concheiro |
Related Documents
:
|
7173297 - Effect of food on bioavailability of chloroquine. 17443397 - Parallel monitoring of plasma and intraluminal drug concentrations in man after oral ad... 15380887 - Phloridzin improves absorption of genistin in isolated rat small intestine. 12813187 - Fast-casual dining: our next eating passion? 15675507 - A novel kinetic method for the speciation of cadmium in river water by micro solvent ex... 6812527 - Biosynthesis of vitamin b12. different pathways in some aerobic and anaerobic microorga... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of pharmaceutics Volume: 180 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 1999 Mar |
Date Detail:
|
Created Date: 1999-04-26 Completed Date: 1999-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 105-11 Citation Subset: IM |
Affiliation:
|
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15706, Santiago de Compostela, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cellulose
/
analogs & derivatives*,
chemistry,
metabolism Drug Stability Drug Storage Hydrogen-Ion Concentration Rhizomucor / metabolism* Tablets / metabolism Theophylline / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Tablets; 58-55-9/Theophylline; 9004-34-6/Cellulose; 9004-64-2/hydroxypropylcellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microviscosity of hydroxypropylcellulose gels as a basis for prediction of drug diffusion rates.
Next Document: Exposure of hemodialysis patients to di-2-ethylhexyl phthalate.