Document Detail

Degradation of bacterial lipopolysaccharide by the slime mould Physarum polycephalum.
MedLine Citation:
PMID:  373869     Owner:  NLM     Status:  MEDLINE    
A strain of the acellular slime mould Physarum polycephalum degraded lipopolysaccharides (LPS) from a variety of bacteria. The anticomplementary (AC) activity of LPS was greatly reduced, as was the content of lauric, myristic, and palmitic acids, and the ability to sensitize erythrocytes to agglutination by antibody. These results indicate that Physarum has enzymes which reduce the lipid A moiety of LPS. In contrast, 2-keto-3-deoxy-D-manno-actanoic acid (KDO), immunodominant sugars, and beta-hydroxymyristic acid were scarcely affected. Both supernates and plasmodial extracts of Physarum had LPS-degradative activity and were able to attack both purified LPS and LPS in killed bacteria.
J N Saddler; J G Coote; A C Wardlaw
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of microbiology     Volume:  25     ISSN:  0008-4166     ISO Abbreviation:  Can. J. Microbiol.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372707     Medline TA:  Can J Microbiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
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MeSH Terms
Biodegradation, Environmental
Escherichia coli
Hemagglutination Inhibition Tests
Hot Temperature
Lipopolysaccharides / analysis,  immunology,  metabolism*
Physarum / metabolism*
Reg. No./Substance:

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