Document Detail

Degradation of bacterial lipopolysaccharide by the slime mould Physarum polycephalum.
MedLine Citation:
PMID:  373869     Owner:  NLM     Status:  MEDLINE    
A strain of the acellular slime mould Physarum polycephalum degraded lipopolysaccharides (LPS) from a variety of bacteria. The anticomplementary (AC) activity of LPS was greatly reduced, as was the content of lauric, myristic, and palmitic acids, and the ability to sensitize erythrocytes to agglutination by antibody. These results indicate that Physarum has enzymes which reduce the lipid A moiety of LPS. In contrast, 2-keto-3-deoxy-D-manno-actanoic acid (KDO), immunodominant sugars, and beta-hydroxymyristic acid were scarcely affected. Both supernates and plasmodial extracts of Physarum had LPS-degradative activity and were able to attack both purified LPS and LPS in killed bacteria.
J N Saddler; J G Coote; A C Wardlaw
Related Documents :
7295649 - Carbon-13 nuclear magnetic resonance spectroscopic study of teichuronic acid from micro...
18316129 - Methodology to label mixed carbohydrate components by apts.
11791709 - Structural characterization and immunomodulating activity of a complex glucan from spor...
404289 - Metabolic role of free mycolic acids in mycobacterium tuberculosis.
236829 - The structure of klebsiella serotype ii capsular polysaccharide.
196639 - Structural studies on the sialic acid polysaccharide antigen of escherichia coli strain...
14197889 - Amino acid accumulation in ethionine-resistant saccharomyces cerevisiae.
1980429 - Reexamination of dopamine as the prolactin-release inhibiting factor (pif): supplementa...
3747739 - Effect of nutritional status on the fatty acid composition of rat liver and cultured he...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of microbiology     Volume:  25     ISSN:  0008-4166     ISO Abbreviation:  Can. J. Microbiol.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372707     Medline TA:  Can J Microbiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biodegradation, Environmental
Escherichia coli
Hemagglutination Inhibition Tests
Hot Temperature
Lipopolysaccharides / analysis,  immunology,  metabolism*
Physarum / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bile acids of a 3200-year-old Egyptian mummy.
Next Document:  Effect of cardiopulmonary bypass and hypothermia on pancreatic endocrine function and peripheral uti...