Document Detail

Degradation Study of Carnosic acid, Carnosol, Rosmarinic Acid and Rosemary Extract (Rosmarinus Officinalis L.) assessed using HPLC.
MedLine Citation:
PMID:  22881034     Owner:  NLM     Status:  Publisher    
Rosemary, whose major caffeoyl-derived and diterpenoid ingredients are rosmarinic acid, carnosol and carnosic acid, is an important source of natural antioxidants and is being recognized increasingly as a useful preservative, protectant, and even as a potential medicinal agent. Understanding the stability of these components and their mode of interaction in mixtures is important if they are to be utilized to greatest effect. A study of the degradation of rosmarinic acid, carnosol, carnosic acid and a mixture of the three was conducted in ethanolic solutions at different temperatures and light exposure. As expected, degradation increased with temperature. Some unique degradation products were formed with exposure to light. Several degradation products were reported for the first time. The degradation products were identified by HPLC/MS/MS, UV and NMR. The degradation of rosemary extract in fish oil also was investigated and much slower rates of degradation were observed for carnosic acid. In the mixture of the three antioxidants, carnosic acid serves to maintain levels of carnosol, though it does so at least in part at the cost of its own degradation.
Ying Zhang; Jonathan Smuts; Edra Dodbiba; Rekha Rangarajan; John Lang; Daniel W Armstrong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-11
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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