Document Detail


Degradation and Drug Release in Calcium Polyphosphate Bioceramics: An MRI-Based Characterization.
MedLine Citation:
PMID:  22659178     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Degradable, bioceramic bone implants made of calcium polyphosphate (CPP) hold potential for controlled release of therapeutic agents in the treatment of localized bone disease. MRI techniques for non-invasively mapping fluid distribution, T(1) and T(2) relaxation times, and the apparent diffusion coefficient (ADC) were performed in conjunction with a drug elution protocol to resolve free and bound water components within the material microstructure in two CPP formulations (G1 and G2). The T(2) maps provided the most accurate estimates of free and bound water, and showed that G1 disks contained a detectable free water component at all times, with drug release dominated by a Fickian diffusion mechanism. Drug release from G2 disks was characterized by a combined diffusional/structural relaxation mechanism, which may be related to the gradual infiltration of a free water component associated with swelling and/or chemical degradation.
Authors:
Joshua M Bray; Mark J Filiaggi; Chris V Bowen; Steven D Beyea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-29
Journal Detail:
Title:  Acta biomaterialia     Volume:  -     ISSN:  1878-7568     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Institute for Biodiagnostics (Atlantic), Neuroimaging Research Laboratory, National Research Council of Canada, 1796 Summer Street, Halifax, Nova Scotia, Canada B3H 3A7; Department of Physics, Dalhousie University, Halifax, Nova Scotia, Canada.
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