| Degradable magnesium-based implant materials with anti-inflammatory activity. | |
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MedLine Citation:
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PMID: 23203562 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The objective of this study was to prepare a new biodegradable Mg-based biomaterial, which provides good mechanical integrity in combination with anti-inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a potential anti-inflammatory core. The new degradable Mg-Zn-Ag biomaterial was prepared by zone solidification technology and extrusion. The mechanical properties were mostly enhanced by fine grain strengthening. In addition, the alloys exhibited good cytocompatibility. The anti-inflammatory function of degradation products was identified by both interleukin-1α and nitric oxide modes. The anti-inflammatory impact was significantly associated with the concentration of silver ion. It was demonstrated that Mg-Zn-Ag system was a potential metallic stent with anti-inflammatory function, which can reduce the long-term dependence of anti-inflammatory drug after coronary stent implantation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012. |
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Authors:
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Qiuming Peng; Kun Li; Zengsheng Han; Erde Wang; Zhigang Xu; Riping Liu; Yongjun Tian |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-3 |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: - ISSN: 1552-4965 ISO Abbreviation: J Biomed Mater Res A Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, People's Republic of China. pengqiuming@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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