| Deglycosylation of apo B-containing lipoproteins increase their ability to aggregate and to promote intracellular cholesterol accumulation in vitro. | |
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MedLine Citation:
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PMID: 19085234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sub-fractions of all apo B-100 containing lipoproteins (low density lipoproteins, very low density lipoproteins and intermediate density lipoproteins) with reduced contents of sialic acid were found in vivo in human blood. These lipoproteins were inclined to spontaneously form aggregates and were able to stimulate accumulation of cholesterol in cells cultured from human aortic intima. In vitro treatment of apo B-containing lipoproteins with 2,6- and 2,3-specific sialidases, alpha-mannosidase, endoglycosidases F1 or F2 or peptide-N-glycanase F also stimulated aggregation and increased the ability of these particles to potentiate cholesterol accumulation in cells of the intact human aortic intima. So, deglycosylation of various apo B-containing lipoproteins possibly occurs in the blood, decreases their resistance to aggregation and increases the ability of these particles to stimulate accumulation of cholesterol in human aortic intima cells, thereby increasing their atherogenic potential. |
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Authors:
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D V Aksenov; L A Medvedeva; T A Skalbe; I A Sobenin; V V Tertov; Z A Gabbasov; E V Popov; A N Orekhov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of physiology and biochemistry Volume: 114 ISSN: 1744-4160 ISO Abbreviation: Arch. Physiol. Biochem. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9510153 Medline TA: Arch Physiol Biochem Country: England |
Other Details:
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Languages: eng Pagination: 349-56 Citation Subset: IM |
Affiliation:
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Institute of Experimental Cardiology, Russian Cardiology Research Center, Moscow, Russia. denaks@mail.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoprotein B-100 / metabolism* Atherosclerosis / metabolism Cholesterol / metabolism* Glycoside Hydrolases / metabolism Glycosylation Humans Intracellular Space / metabolism* Lipoproteins / blood, chemistry*, metabolism* Lipoproteins, VLDL / blood Male Mannose / metabolism Middle Aged N-Acetylneuraminic Acid / metabolism Protein Binding |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein B-100; 0/Lipoproteins; 0/Lipoproteins, VLDL; 131-48-6/N-Acetylneuraminic Acid; 31103-86-3/Mannose; 57-88-5/Cholesterol; EC 3.2.1.-/Glycoside Hydrolases |
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