| Deglutitive upper esophageal sphincter relaxation: a study of 75 volunteer subjects using solid-state high-resolution manometry. | |
| | |
MedLine Citation:
|
PMID: 16645162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study aimed to use a novel high-resolution manometry (HRM) system to establish normative values for deglutitive upper esophageal sphincter (UES) relaxation. Seventy-five asymptomatic controls were studied. A solid-state HRM assembly with 36 circumferential sensors spaced 1 cm apart was positioned to record from the hypopharynx to the stomach. Subjects performed ten 5-ml water swallows and one each of 1-, 10-, and 20-ml volume swallows. Pressure profiles across the UES were analyzed using customized computational algorithms that measured 1) the relaxation interval (RI), 2) the median intrabolus pressure (mIBP) during the RI, and 3) the deglutitive sphincter resistance (DSR) defined as mIBP/RI. The automated analysis succeeded in confirming bolus volume modulation of both the RI and the mIBP with the mean RI ranging from 0.32 to 0.50 s and mIBP ranging from 5.93 to 13.80 mmHg for 1- and 20-ml swallows, respectively. DSR was relatively independent of bolus volume. Peak pharyngeal contraction during the return to the resting state postswallow was almost 300 mmHg, again independent of bolus volume. We performed a detailed analysis of deglutitive UES relaxation with a novel HRM system and customized software. The enhanced spatial resolution of HRM allows for the accurate, automated assessment of UES relaxation and intrabolus pressure characteristics, in both cases confirming the volume-dependent effects and absolute values of these parameters previously demonstrated by detailed analysis of concurrent manometry/fluoroscopy data. Normative values were established to aid in future clinical and investigative studies. |
| | |
Authors:
|
Sudip K Ghosh; John E Pandolfino; Qing Zhang; Andrew Jarosz; Peter J Kahrilas |
Publication Detail:
|
Type: Evaluation Studies; Journal Article Date: 2006-04-27 |
Journal Detail:
|
Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 291 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-08-10 Completed Date: 2006-09-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: G525-31 Citation Subset: IM |
Affiliation:
|
Northwestern University, Feinberg School of Medicine, Div. of Gastroenterology, Dept. of Medicine, 676 N. St. Clair St., Suite 1400, Chicago, IL 60611, USA. s-ghosh@northwestern.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Deglutition / physiology* Diagnosis, Computer-Assisted / methods* Equipment Design Equipment Failure Analysis Esophagus / physiology* Female Humans Male Manometry / instrumentation*, methods* Middle Aged Peristalsis / physiology* Reproducibility of Results Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: IL-1beta signaling in cat lower esophageal sphincter circular muscle.
Next Document: Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma.