Document Detail

Degenerative processes in the pathogenesis of pulmonary alveolar lipoproteinosis.
MedLine Citation:
PMID:  202067     Owner:  NLM     Status:  MEDLINE    
Electron microscopy in an infant of 4 months with pulmonary alveolar lipoproteinosis showed filling of the alveoli with osmiophilic lamellar bodies. Similar structures were present in the cytoplasm of type I alveolar epithelial cells and to a lesser extent in the capillary endothelium and interstitium. These changes represent widespread degenerative processes in the lung caused by an unidentified cytotoxic agent. In this patient the disease is comparable to the drug-induced cytotoxic animal model and differs from the dust-induced hypersecretory animal model.
D Jacobovitz-Derks; B Corrin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histology     Volume:  376     ISSN:  0340-1227     ISO Abbreviation:  Virchows Arch A Pathol Anat Histol     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  7505137     Medline TA:  Virchows Arch A Pathol Anat Histol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  165-74     Citation Subset:  IM    
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MeSH Terms
Epithelium / ultrastructure
Inclusion Bodies / ultrastructure
Pulmonary Alveolar Proteinosis / pathology*
Pulmonary Alveoli / ultrastructure

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